Application S-Adenosylmethionine in Hepatoprotective Nutritional Supplement Feeds for Dogs and Cats
SAM-e, short for S-adenosylmethionine, is the activated form of methionine and a vital methyl donor for the liver.
Glucocorticoids and chemotherapeutic drugs tend to induce oxidative liver injury in dogs.
Controlled trials demonstrate that dietary supplementation with SAM-e stabilizes glutathione levels in canine red blood cells, enhances hepatic antioxidant reserves, and counteracts prednisone-induced oxidative imbalance.
In feline models of acetaminophen toxicity, SAM-e accelerates the clearance of Heinz bodies, reduces the risk of oxidative hemorrhage in visceral organs, and exerts definite detoxifying and liver-protective effects.
With its multiple functions including antioxidation, hepatic cell membrane stabilization, anti-inflammation and detoxification, SAM-e serves as an excellent additive for liver-protective feeds for dogs and cats.
It can assist in the treatment of toxic, drug-induced and inflammatory liver diseases, and its efficacy can be further potentiated when compounded with silymarin complexes.
SAM-e, short for S-adenosylmethionine, is the activated form of methionine and a vital methyl donor for the liver.
