GSH WORLD | How much do you know about the Nicotinamide mononucleotide

 

  About Nicotinamide Mononucleotide

Nicotinamide mononucleotide (NMN) play an important role in the production of human cell energy, which is involved in the synthesis of intracellular NAD (nicotinamide adenine dinucleotide, an important coenzyme for cell energy conversion).Niacinamide (nicotinamide) is a derivative of vitamin B3, also known as niacin. NAD+ is a molecule that holds a variety of functions within the body, mainly through facilitation of cell-signaling enzymes called sirtuins. These enzymes are crucial for normal functioning, with SIRT1 (there are 7 sirtuins) being particularly unique. Research has shown it to be highly active following caloric restriction, which itself brings multiple benefits, including signs of an extending lifespan. Sure enough, further tests have revealed that elevated levels of SIRT1 can lead to protection from metabolic decline and disease.

The extra baggage that comes along with getting older, quite plainly, is pretty heavy. Being more susceptible to pains and aches and having less energy, all while your metabolism is screeching to a stop, is something that no one looks forward to. But, as current science stands, it remains an inevitability.

However, that doesn t mean there isn t a way to slow this deterioration down!    

Most of the symptoms of aging are directly related to how well our mitochondria are working. These powerhouses run on a specific fuel called NAD+, and this energy source seems to grow harder to find as we get older. Without it, we produce less ATP, and our bodies start to become liable to a variety of diseases and undesirable symptoms. Nicotinamide mononucleotide (NMN) providing you the best way to keep NAD+ production in high-gear. 

As we know Nicotinamide mononucleotide (NMN) is popular to use on its own and is often marketed by supplement brands towards anti-aging and general wellness markets. We also believe there are applications for this in energy supplements, work out enhancement, blood sugar control, and even weight loss, but we leave it to you to formulate fantastic products – we simply provide the best NMN on the market.
 

Why not intake NAD+ directly?

As NAD+ molecules are relatively large, so It’s difficult for NAD+ intaken from supplements to penetrate the cell membrane and then enter the cell interior. While NMN molecules can easily cross the cell membrane and enter the cell interior. Once entering the cell interior, two of NMN molecules will be combined spontaneously to form an NAD+ molecule, so that NAD+ can take effect in human body.
Therefore, regular intake of this substance can effectively increase the content in our body, thus helping we are repair DNA damage and anti-aging

 

Is NMN safe and reliable for long-term use?

NMN is a naturally occurring substance found in the human body. It is also found in many foods and is completely natural and harmless.Studies have shown that supplementation of NMN does not affect the activity of various enzymes in the complementary synthesis pathway, Oral NMN has no effect on the activity of NAMPT, PARP, NMNAT and other enzymes in the synthetic pathway, and directly changes the level of NAD+ in our body.

Some common NMN rich foods are listed in CELL magazine as follows:

 

Name	mg/100g
Tomato	0.26-0.30
Mushroom	0.01-1.01
Avocado	0.36-1.60
Green pea	0.47-1.88
Broccoli	0.25-1.12
Fish	0.22
Animal meat	0.03-0.42

 

 

The research shows that the old people over 65 years old with 70 kg should be supplemented with about 600 mg of NMN every day, and the young people around 45 years old should be supplemented with about 300 mg. This is equivalent to eating about 32kg of green pea or 54kg of broccoli every day, and ensuring complete absorption. It's clear that is not possible at all, so it is particularly important to supplement NMN from non-food sources.