As we age, the reduction of NAD+ levels leads to the decline of DNA repair ability and the accumulation of DNA damage, which drives the aging process. NAD+ participates in cellular respiration in cells and promotes metabolic processes (such as oxidation of glucose, fat, and amino acids). NAD+ is not only a coenzyme for hundreds of redox reactions in living cells, but also serves as a substrate to participate in the regulation of various physiological functions such as cell survival, apoptosis, DNA repair, immune response, and circadian rhythm.
Studies have found that the decline in NAD+ levels will lead to abnormal communication between the nucleus and mitochondria, resulting in reduced DNA repair ability, accumulation of DNA damage, and triggering aging. As the precursor of NAD+, NMN synthesizes NAD+ through the NAD+ salvage synthesis pathway in cells. Supplementing NMN can increase the body's NAD+ level, which is greatly reduced due to aging and unhealthy conditions, and has great potential for delaying aging, preventing and treating various diseases.
In May 2019, a study officially published in "Ienatu" found that aging affects the quality of oocytes by reducing NAD+ levels, which eventually leads to female physiological and fertility disorders. In a strict sense, aging is directly related to female physiology.
NMN, the NAD+ synthesis mediated by it has a protective effect on aging oocytes. It was found that the longer the mice ingested NMN, the more significant the increase in the blastocyst formation rate of the oocyte and the development of the inner cell mass of the blastocyst. These two indicators are important factors in predicting the final pregnancy success rate, and their improvement indirectly indicates the improvement of fertility.
Current experiments at the cell level have shown that NMN intake (2g/L) can significantly improve the quality of oocytes in aged mice, thereby restoring fertility. With this conclusion in mind, the research set out to test whether NMN could actually restore fertility in older female mice on a "clinical" level.
The data shows that the pregnancy rate, live birth rate, and litter size of the 0.5g/L NMN intake group have all been greatly improved.
Supplementation with NMN restores meiotic maturation in aged oocytes, restores kinetochore microtubule attachment to ensure euploid oocytes in aged oocytes, rescues cortical granules and Ovastacin in aged oocytes.
*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.