Meet Sodium Creatine Phosphate
Sodium Creatine Phosphate (Creatine phosphate disodium salt)
Phosphocreatine (CP) is one of the key substances involved in cellular energy metabolism in the human body. As an endogenous molecule, CP serves as an immediate donor to replenish adenosine triphosphate (ATP) and acts as a “buffer” that keeps the ATP concentration constant in high-energy-consuming cells. It was first discovered in 1927. Sodium creatine phosphate is a novel energy-supplying agent that can provide exogenous energy to cardiac muscle cells, maintain high-energy phosphate levels, and promote the synthesis of adenine nucleotides.
Areas of Application
Medical field
Primarily used in heart failure, myocardial infarction, and peri-operative cardioprotection. It is also applied in neonatal hypoxic-ischemic encephalopathy, pediatric myocarditis, prevention and treatment of chemotherapy-induced cardiotoxicity, and cardiopulmonary resuscitation.
Dietary supplement field
Can be incorporated into sports-nutrition products to potentially enhance muscle function and improve muscular performance.
Manufacturing technology
Sodium creatine phosphate is produced either by an enzymatic or by a chemical synthetic route. Regardless of the method, the clinically used preparations are always formulated as the disodium salt.
Combination therapy
Current data suggest that, on the basis of routine antiviral and cardio-supportive treatment, adding sodium creatine phosphate together with vitamin C or coenzyme Q10 may offer synergistic benefits: the former replenishes myocardial energy and stabilizes cell membranes, while vitamin C scavenges free radicals via its antioxidant action and coenzyme Q10 protects mitochondrial function. Some pediatric patients thus treated showed trends toward further improvements in myocardial enzyme profiles, inflammatory markers, and overall efficacy, without evident additional adverse effects. However, limited sample sizes, treatment durations, and observation time-points mean these differences still require confirmation in larger studies; clinical decisions should therefore be made cautiously on an individual basis.
References
[1] Hao Hai-ju, Wang Jun, Zhang Jun-qing, et al. Effect of sodium creatine phosphate combined with vitamin C on viral myocarditis in children. Chinese Journal of Rational Drug Use, 2024, 21(06): 87-93.
[2] Wang Chun-juan. Efficacy of coenzyme Q10 combined with sodium creatine phosphate in treating pediatric viral myocarditis. Cardiovascular Disease Journal of Integrated Traditional Chinese and Western Medicine (Electronic), 2023, 11(06): 20-22. DOI: 10.16282/j.cnki.cn11-9336/r.2023.06.023.
*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.
by GSHWORLD
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