widespread presence of L-carnosine

by: GSHWORLD Time: 2021-03-18 Classify: Product News

L-carnosine (β-alanyl-L-histidine) and its analogs (such as homocarnosine and anserine) are naturally active dipeptides widely found in mammalian brains, L-Carnosine muscles and other important tissues.

Since the discovery of the active peptide for more than one hundred years, L-Carnosine a large number of studies have found or proved that L-carnosine has significant anti-oxidation, elimination of intracellular free radicals, L-Carnosine anti-aging and other activities, and it is clinically used for hypertension and heart Adjuvant treatment of diseases, L-Carnosine senile cataracts, ulcers, anti-tumor, and promotion of wound healing.

Because of its strong antioxidant activity, L-Carnosine low toxic and side effects and various physiological activities, the active peptide and its derivatives have been widely used in the fields of medicine, L-Carnosine health care, hygiene, cosmetics, etc., and the market space is broad.

At present, L-Carnosine the production of L-carnosine mainly uses chemical synthesis.

There are many existing chemical synthesis methods, L-Carnosine which can be divided into two main categories: (1) Use β-alanine to participate in the synthesis.

The main route is to condense β-alanine with protected L-histidine after amino protection and carboxyl activation, L-Carnosine and then remove the protective group to obtain L-carnosine.

Due to the difference of each protecting group, L-Carnosine this route leads to more synthetic routes.

The commonly used method is to use phthalic anhydride and β-alanine to generate phthaloyl-β-alanine to protect the amino group, L-Carnosine and the carboxyl group reacts with thionyl chloride to generate phthaloyl-β-alanine.

The acid chloride forms a peptide bond with the protected L-histidine and then deprotects the group to obtain the product.

This route is more complicated, the yield is low, L-Carnosine the peptide bond is easily racemized during the formation of the peptide bond, which affects the purity of the product, and the solvent consumption is large, L-Carnosine which is easy to cause environmental pollution;

Reaction without β-alanine:

The main principle is that L-histidine first forms peptide bonds with different β-alanine precursors, L-Carnosine and then is further converted into carnosine.

The commonly used route is under the action of sodium alkoxide, L-histidine and ethyl cyanoacetate undergo an acylation reaction to obtain cyanoacetyl-L-histidine, L-Carnosine which is reduced by catalytic hydrogenation to obtain L-carnosine.

This route is relatively simple, omits the process of protecting and deprotecting different groups, L-Carnosine and avoids the occurrence of racemization reaction, but it requires anhydrous operation and strict requirements.

At the same time, L-Carnosine ethyl cyanoacetate is an environmental toxic substance, L-Carnosine which is easy to cause water pollution and toxic reactions.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.