Adenosylmethionine powder Q&A

 

S-adenosylmethionine (SAMe) is an endogenous sulfur-containing compound synthesized catalytically from adenosine triphosphate and methionine. In vivo, it participates in a variety of metabolic reactions, such as the synthesis of nucleic acids, proteins, lipids and secondary metabolites.

1. What are the uses of adenosylmethionine?

SAMe is the active precursor of sulfur-containing compounds such as glutathione, cysteine, taurine and coenzyme A. SAM has anti-inflammatory and connective effects, which is beneficial to maintaining the health of bones and joints. As early as the 1970s, , SAM has been used to treat arthritis. In the mid-1980s, SAM was used as an antidepressant drug. In addition, it is also used to treat liver function disorders and is also used to prevent cardiovascular disease and anti-aging. Popular health supplement.

2. Can SAMe be used to treat ADHD?

Attention deficit hyperactivity disorder (ADHD) is a disorder that affects people's behavior. Early studies showed that ADHD patients improved after using SAM. However, subsequent trials also evaluated the possibility of SAMe treatment, although SAMe treatment seems to be safe. , well tolerated, but no significant benefit on ADHD symptoms was found, and more research may need to be waited for.

3. Can SAMe be taken with food?

Generally speaking, it is not recommended to take it with food. If you want to better absorb and exert the effect of SAMe, it is recommended to consult a more professional nutrition and health care provider or medical staff based on your own physical condition. The effectiveness of SAMe may vary depending on the person. Pharmacokinetics vary.

4. Can SAMe be taken for a long time? is it safe?

SAMe is generally considered safe and well-tolerated. However, high doses of SAMe may cause stomach or abdominal discomfort. If long-term use is required, it is recommended to consult a medical professional.

references:

• [1] Sarris J, Byrne G J, Stough C, et al. Nutraceuticals for major depressive disorder-more is not merrier: An 8-week double-blind, randomized, controlled trial[J]. Journal of affective disorders, 2019, 245 : 1007-1015.

• [2] Wan HongGui W H G, Guo YiDan G Y D, Cai Heng C H, et al. Development and market application of S-adenosyl-L-methionine[J]. 2008.

• [3] Shekim WO, Antun F, Hanna GL, McCracken JT, Hess EB. S-adenosyl-L-methionine (SAM) in adults with ADHD, RS: preliminary results from an open trial. Psychopharmacol Bull. 1990;26(2) ):249-53. PMID: 2236465.

• [4] Green T, Steingart L, Frisch A, Zarchi O, Weizman A, Gothelf D. The feasibility and safety of S-adenosyl-L-methionine (SAMe) for the treatment of neuropsychiatric symptoms in 22q11.2 deletion syndrome: a double-blind placebo-controlled trial. J Neural Transm (Vienna). 2012 Nov;119(11):1417-23. doi: 10.1007/s00702-012-0831-x. Epub 2012 Jun 8. PMID: 22678699.

• [5] Arnold L E, Hurt E, Lofthouse N. Attention-deficit/hyperactivity disorder: dietary and nutritional treatments[J]. Child and Adolescent Psychiatric Clinics, 2013, 22(3): 381-402.

• [6] Sakurai H, L Carpenter L, R Tyrka A, Price LH, I Papakostas G, Dording CM, Yeung AS, Cusin C, Ludington E, Bernard-Negron R, Fava M, Mischoulon D. Dose increase of S-Adenosyl -Methionine and escitalopram in a randomized clinical trial for major depressive disorder. J Affect Disord. 2020 Feb 1;262:118-125. doi: 10.1016/j.jad.2019.10.040. Epub 2019 Oct 31. PMID: 31733455; PMCID : PMC6917851.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.