What is the main use of SAMe?

 

Adenosylmethionine is a physiologically active molecule that exists in various tissues and body fluids of the human body. It is composed of the sulfur-containing amino acid methionine and the body's main energy substance adenosine triphosphate (ATP), and has important biochemical functions. This compound is usually sold as a sulfate salt because it is less stable in air and light. It is a compound widely used in medicine, agriculture, bioengineering and other fields.

Applications of S-Adenosyl-L-Methionine Disulfate Tosylate:

1. Medical applications

SAMe is a major donor of methyl groups in cells, a key regulator of most biological pathways, and an important antioxidant. SAMe is present in all cells and cellular compartments, the liver is considered the factory of SAMe, and normal SAMe levels are essential for liver health.

Anti-inflammatory activity: S-adenosylmethionine p-toluenesulfonate sulfate is used to treat chronic liver disease and has anti-inflammatory effects.

Improves mood, liver support, and joint comfort: It is thought to be good for mood and liver health, and may also have a positive impact on joint comfort.

2.Agricultural applications

Salt stress is considered to be one of the major factors limiting crop growth and yield. S-adenosylmethionine (SAM) plays an important role in many cell organelles with the help of SAM transporters. It is also a precursor for the synthesis of substances such as ethylene (ET), polyamines (PA), betaine, and lignin. SAM, as a synthetic precursor for the synthesis of ET and PA, regulates plant salt stress by controlling the dynamic homeostasis of ET and PA, so that SAM biosynthesis affects the response to salt stress and plays a very important role in salt stress.

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references:

[1] Barbier-Torres L, Chhimwal J, Kim SY, Ramani K, Robinson A, Yang H, Van Eyk J, Liangpunsakul S, Seki E, Mato JM, Lu SC. S-Adenosylmethionine Negatively Regulates the Mitochondrial Respiratory Chain Repressor MCJ in the Liver. Int J Biol Sci. 2024 Jan 27;20(4):1218–37. doi: 10.7150/ijbs.90104. PMCID: PMC10878152.

[2] Yang L, Wang X, Zhao F, Zhang X, Li W, Huang J, Pei X, Ren X, Liu Y, He K, Zhang F, Ma X, Yang D. Roles of S-Adenosylmethionine and Its Derivatives in Salt Tolerance of Cotton. Int J Mol Sci. 2023 May 30;24(11):9517. doi: 10.3390/ijms24119517. PMID: 37298464; PMCID: PMC10253415.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.