A large number of studies have found that bioactive peptides can prevent and treat the occurrence and development of chronic diseases through anti-oxidative stress, improving immune function and anti-inflammatory response. As a special nutrient substance in nutritional support and treatment, biologically active polypeptide has high clinical application value.
Antioxidative Stress Effects of Bioactive Peptides
Sepsis, systemic inflammatory response and acute respiratory distress syndrome (ARDS) are common and very dangerous complications in clinical intensive care (ICU), with a mortality rate of 10%-50% in critically ill patients. These conditions are currently believed to be due to severe oxidative stress.
Oxidative stress (oxidative stress, OS) refers to the imbalance between oxidation and anti-oxidation in the body, which tends to oxidize, leading to inflammatory infiltration of neutrophils, increased secretion of proteases, and production of a large number of oxidized intermediates. The main consequence of oxidative stress is to cause oxidation damage to biological macromolecules such as protein, fat, nucleic acid, etc. Diseases such as Alzheimer's disease and an important cause of human aging.
There is a double close relationship between nutrition and oxidative stress. Nutrients can generate reactive oxygen species and intermediate product free radicals during in vivo metabolism; transition metal trace elements, such as iron ions and copper ions, can promote the generation of reactive oxygen species. On the other hand, a balanced diet and reasonable nutrition can enhance the body's antioxidant defense function; some nutrients and food components can directly or indirectly exert antioxidant effects.
Peptides from certain food sources have antioxidant effects, among which glutathione, which is widely present in animals and plants, is the most familiar.
Glutathione mainly acts as a reversible hydrogen donor through the conversion of its sulfhydryl oxidation-reduction state, and plays an antioxidant role in the aqueous phase of the cell.
In addition, glutathione can also revive sulfhydryl enzymes damaged by reactive oxygen species and participate in the redox process in the body. It can combine with peroxides and free radicals, inhibit reactive oxygen species from damaging sulfhydryl groups, and protect proteins containing sulfhydryl groups in cell membranes. Prevents free radicals from causing organ damage and various diseases.
Appropriate supplementation of bioactive peptides through nutritional support means to reduce peroxidative damage during critical stress and reduce harmful or excessive inflammatory responses has become an important means of critical illness treatment.