Research on glutathione in animal production

 

Research on glutathione (GSH) in animal production mainly focuses on improving the antioxidant performance, growth performance, stress resistance and reproductive ability of animals. In recent years, it has been obtained in aquatic animals, pigs, chickens, sheep and cattle. Extensive research and application.

1. GSH can significantly improve the antioxidant performance of animals.

Studies have shown that adding GSH to the diet of weaned piglets at the age of 28 days can significantly increase the activity of GSH-Px and IgG content in serum of weaned piglets. In addition, GSH can significantly increase the content of GSH and IgG in broiler serum; the activities of antioxidant enzymes such as SOD and CAT in the serum of fattening sheep in the test group supplemented with GSH were significantly higher than those in the control group.

In addition, the antioxidant properties of GSH have also been well verified in aquatic products, mutton sheep and other animals.

2. GSH can significantly improve the growth performance of animals.

Studies have shown that adding 20mg/kg GSH to the diet of fattening pigs can significantly improve the daily gain, carcass lean meat rate and feed utilization efficiency of test pigs; in the study of weaned piglets, it was found that the serum IGF-1 of test group pigs The level of IGF-1 mRNA was significantly higher than that of the control group, and the expression of IGF-1 mRNA in liver and muscle was also significantly higher than that of the control group.

In chicken research, it was found that GSH can significantly improve the weight gain rate and feed utilization rate of yellow feather broiler chickens; GSH can also significantly improve the proliferation ability, glucose absorption function and cell membrane enzyme activity of chicken small intestinal epithelial cells.

In the study of sheep, after adding GSH to the diet, the weight gain rate and feed utilization rate of mutton sheep were significantly improved; GSH can also significantly increase the serum IGF-1 and GH levels of mutton sheep.

In addition, many studies have found that the production performance of aquatic animals in the GSH test group was significantly improved.

3. GSH can significantly improve the anti-stress ability of animals, and improve the resistance and survival rate of animals in adverse environments.

In the study of aquatic animals, it was found that GSH can effectively reduce the stress of microcystins on peltago carp and grass carp, and improve the ability to resist stress.

In chicken research, it was found that GSH can improve the disease resistance of chicks to coccidiosis and the survival rate of chicks; GSH can also inhibit the adverse effect of high concentration copper ions on the mitochondria of broiler hepatocytes, and protect the mitochondrial respiratory chain complex of broilers. body.

4. GSH has a good effect on cell preservation in animal breeding.

In pig studies, it was found that adding 1mmol/L glutathione to the culture medium can reduce the generation of ROS during semen freezing, and significantly improve the viability, vitality and acrosome integrity of frozen sperm after thawing.

In the study of cattle, it was found that adding 3.2mmol/L GSH to the culture medium could significantly improve the vitality, longevity and fertilization rate of bovine sperm after cryopreservation and thawing.

In addition, in the process of embryonic development in vitro, adding GSH to the culture medium can improve the developmental success rate and survival rate of embryos at various stages.

In short, the unique molecular structure of GSH enables it to have various physiological functions such as anti-oxidation, anti-stress, and detoxification, so it plays a very important role in the healthy growth of animals. With the deepening of research, the relevant mechanism and principle of GSH's effect on animals will become clearer, and its application prospects will be broader.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.