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Citicoline sodium can improve cerebral circulation by reducing cerebrovascular resistance and increasing cerebral blood flow. It can also enhance the function of the ascending reticular activation system of the brain stem, enhance the function of the vertebral system, and improve motor paralysis, so it has a certain role in promoting the recovery of brain function and recovery.
Citicoline sodium injection can quickly enter the blood, and some of it can enter the brain tissue through the blood-brain barrier. The choline part becomes a good methylation donor in vivo, which can trans methylate a variety of compounds, and about 1% of the choline is excreted from the urine.
| Product Name: | Citicoline sodium |
| Synonyms: | P'-[2-(TRIMETHYLAMMONIO)ETHYL]ESTER CYTIDINE 5'-(TRIHYDROGEN DIPHOSPHATE) INNER SALT MONOSODIUM; cytidine 5'-(trihydrogen diphosphate) p'-[2-(trimethylammonio)ethyl] ester inner salt monosodium salt; CYTIDINE-5'-DIPHOSPHOCHOLINE MONOSODIUM SALT; CYTIDINE-5'-DIPHOSPHOCHOLINE, NA; CYTIDINE-5'-DIPHOSPHOCHOLINE, SODIUM; CYTIDINE 5'-DIPHOSPHOCHOLINE SODIUM SALT; CYTIDINE 5'-DIPHOSPHOCHOLINE SODIUM SALT DIHYDRATE; CITICOLINE SODIUM SALT |
| CAS: | 33818-15-4 |
| MF: | C14H25N4NaO11P2 |
| MW: | 510.31 |
| EINECS: | 251-689-1 |
| Melting point | 259-268°C (dec.) |
| alpha | D20 +12.5° (c = 1.0 in H2O) |
| storage temp. | -20℃ |
| solubility | H2O: 100mg/mL |
| form | solid |
| color | white |
| Water Solubility | Soluble in water (100 mg/ml). |
| λmax | 280nm(HCl aq.)(lit.) |
| Merck | 13,2343 |
| BRN | 4110040 |
| Description | Citicoline is a nucleic acid derivatives, Geiger found that citicoline can restore brain injury in the animal experiments in 1956. Kennedy study confirmed that citicoline can make brain injury recovery in 1957. Takeda pharmaceutical company in Japan developed and produced it in 1961. It was registered in China in 1988, and is currently the best-selling drug among clinical brain diseases. It plays an important role in the synthesis of lecithin, by promoting the synthesis of lecithin and improving brain function. Experiments show that citicoline can enhance the levels of norepinephrine and dopamine in the central nervous system, thereby it can treat cerebrovascular disease, traumatic brain injury and cognitive impairment caused by various reasons, and there are no obvious side effects. |
| Uses | Naturally occurring nucleotide; intermediate in the major pathway of lecitin biosynthesis. Neuroprotective. It is used in the treatment of ischemic stroke and head trauma. Cytidine 5′-diphosphate (CDP) is used as a substrate of CDP (nucleoside diphosphate) kinase (2.7.4.6) to produce CTP in support ofDNA and RNA biosynthesis and of ribonucleotide reductase to product dCMP. Cytidine-5'-diphosphocholine sodium salt hydrate acts as a neuroprotective agent in situations of hypoxia and ischemia. It is used as biosynthetic intermediate of membrane phospholipids. It is a cerebral vasodilator and inhibits PLA2 activation. |
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