Aging is accompanied by cardiovascular diseases, which are related to imbalances in the antioxidant system and mitochondrial dysfunction. Glutathione plays a key role in protecting cells from oxidative damage as an important antioxidant.
Glutathione is synthesized endogenously in cells from glutamate, cysteine and glycine. There are two forms of glutathione in cells, the reduced form (GSH) and the oxidized form (GSSG). Disturbance of intracellular GSH/GSSG balance can cause various diseases such as cardiovascular disease.
Some researchers have used the combination of Shuxuening and reduced glutathione to treat patients with chronic cardiac insufficiency, and the treatment efficiency has been significantly improved. It can be believed that GSH can effectively scavenge free radicals, improve hemodynamics, and expand coronary blood vessels. Lowering blood viscosity and reducing the formation of microthrombi, thereby accelerating the recovery of patients with chronic cardiac insufficiency, improving the therapeutic effect of such patients, and shortening the treatment time, is a treatment method worth promoting.
The effect of exogenous glutathione on the mitochondrial redox state and cardiovascular system function of aged rats was studied. The results showed that the protective and stabilizing mechanism of exogenous glutathione on aged rats was to increase the redox state of the heart tissue. Prototype glutathione content, thus improving the redox status of heart tissue and mitochondria, indicating that the mitochondrial redox status plays an important role in the function of the cardiovascular system, and also confirms that exogenous glutathione can repair cardiovascular disease during the aging process system possibilities. The research results were published in the journal Frontiers in Physiology.
Studies have found that exogenous glutathione has the potential to restore the redox state of cardiac mitochondria. Application of exogenous glutathione may be a useful method to correct not only cardiovascular disorders but also those related to aging and oxidative stress. Instigate functional changes to other related systems.
Oxidative stress promotes the occurrence and development of coronary heart disease by causing lipid peroxidation and oxidative damage to endothelial cells, smooth muscle cells, and macrophages, and the degree of myocardial damage is positively correlated with the decreased level of GSH in myocardial cells. Therefore, exogenous GSH treatment can maintain the balance of GSH and GSSG in the body, stabilize endothelial cells, protect cardiomyocytes, and maintain the normal operation of cardiac function. As a natural low-molecular antioxidant and electron donor, glutathione participates in maintaining cell homeostasis and plays a key role in protecting cells from oxidative stress and inhibiting apoptosis. It is also a xenobiotic detoxification and drug. Necessary for metabolism, etc.