Nicotinamide Mononucleotide (NMN) is a derivative of nicotinamide (NAM), a form of vitamin B3. NMN is a precursor of nicotinamide adenine dinucleotide (NAD+), a coenzyme that plays a vital role in cellular energy metabolism, DNA repair, gene expression and cell signaling. NAD+ levels decline with age and in various diseases, such as diabetes, obesity, neurodegeneration and cancer. This decline is associated with impaired cellular function and increased susceptibility to aging and age-related diseases.
One of the strategies to restore NAD+ levels and delay aging is to supplement with NMN. NMN can be converted to NAD+ by the enzyme nicotinamide phosphoribosyltransferase (NAMPT) or by the salvage pathway in various tissues and organs. NMN can also cross the blood-brain barrier and increase NAD+ levels in the brain. Several animal studies have shown that NMN supplementation can improve glucose metabolism, insulin sensitivity, mitochondrial function, cognitive function, cardiovascular health and lifespan in mice.
However, the bioavailability and stability of NMN are limited by its rapid degradation and low absorption in the gastrointestinal tract. Therefore, there is a need for novel formulations of NMN that can enhance its delivery and efficacy. One of the potential solutions is to use original equipment manufacturer (OEM) NMN, which is a customized form of NMN that can be tailored to the specific needs and preferences of the customers.
OEM NMN can be produced by using different methods, such as microencapsulation, liposomal encapsulation, nanotechnology or chemical modification. These methods can protect NMN from degradation, increase its solubility and permeability, and target its delivery to specific tissues or organs. For example, microencapsulation can coat NMN with a protective layer of polymers or lipids that can prevent its hydrolysis by intestinal enzymes and enhance its absorption by intestinal cells. Liposomal encapsulation can encapsulate NMN in spherical vesicles composed of phospholipids that can fuse with cell membranes and release NMN into the cytoplasm. Nanotechnology can create nanosized particles or carriers that can transport NMN across biological barriers and deliver it to specific sites of action. Chemical modification can alter the structure or charge of NMN to improve its stability and affinity for transporters or receptors.
OEM NMN can also be combined with other ingredients or additives that can synergize with its anti-aging effects. For example, OEM NMN can be mixed with resveratrol, a polyphenol that can activate sirtuins, a family of NAD±dependent enzymes that regulate cellular longevity. OEM NMN can also be blended with antioxidants, vitamins, minerals or herbal extracts that can modulate oxidative stress, inflammation or hormonal balance.
In conclusion, OEM nicotinamide mononucleotide (NMN) is a novel anti-aging supplement that can be customized to enhance its bioavailability and efficacy. OEM NMN can increase NAD+ levels and improve various aspects of cellular function and health. OEM NMN can also be formulated with different methods or ingredients that can optimize its delivery and synergy. OEM NMN may offer a promising strategy to delay aging and prevent age-related diseases.