β-Nicotinamide Mononucleotide (NMN) is a nucleotide with important biological activity and widely exists in various organisms. In recent years, the physiological health-care functions of NMN, especially its effects on delaying aging, have received widespread attention.
Studies by Das et al. have shown that supplementing NMN to mice can improve blood flow and enhance exercise endurance in aged mice by promoting Sirt-1-dependent increase in capillary density. Clinical trials have found that the concentration of coenzyme I in the blood of subjects decreases during intense exercise. Increasing the concentration of coenzyme I in the blood can reduce the inhibition of mitochondrial aerobic respiration caused by oxidative stress, increase electron transfer efficiency and ATP synthesis, and alleviate the effects of oxidative stress. The fatigue level of the tester.
Jia Zhixing et al. studied the effect and mechanism of NMN on ischemia-reperfusion injury (IRI) induced by cardiac death donor livers in rats, and randomly divided SD rats into a sham operation group (Sham group) and an orthotopic liver transplantation group ( OLT group), NMN treatment + orthotopic liver transplantation group (NMN group), NMN + Sirt3 inhibitor (3-TYP) + orthotopic liver transplantation group (NMN + 3-TYP group), observe the postoperative survival of rats in each group condition, pathological changes in liver tissue and liver cell apoptosis, and serum biochemical indicators were detected. The results showed that compared with the Sham group, the OLT group had increased ALT and AST levels, decreased SOD, and increased MDA, while the NMN group could significantly reverse these changes. The survival rates of rats in the Sham group, OLT group, NMN group, and NMN+3-TYP group 7 days after surgery were 100%, 50%, 75%, and 58%, respectively.
The study results also show that NMN supplementation can protect the transplanted liver by upregulating Sirt-3, enhancing liver antioxidant capacity and inducing PINK1/Parkin-mediated mitophagy, alleviating hepatic IRI.
NMN supplementation protects the heart from ischemia/reperfusion injury by reversing ischemia-induced NAD+ reduction, maintains neural stem cell numbers, and restores skeletal muscle mitochondrial function and arterial function in aged mice. Prevents DNA damage and hepatocellular carcinoma formation, improves noise-induced hearing loss, and maintains muscle stem cell function.
NMN has significant effects on type 2 diabetes, obesity, cerebral and cardiac ischemia, heart failure and cardiomyopathy, Alzheimer's disease and other neurodegenerative diseases, corneal damage, macular degeneration and retinal degeneration, acute kidney injury and alcoholic liver disease. It has various degrees of adjuvant treatment for many diseases.
Source of article: Zhang Lizhi, Li Xiaomeng, Li Jing. β-Nicotinamide Mononucleotide: progress in basic and applied research [J]. Acta Nutrition, 2023, 45(04): 320-325. DOI: 10.13325/j.cnki. acta.nutr.sin.2023.04.010.
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