The impact of NMN on diabetes

 

Diabetes is mainly divided into type 1 diabetes (due to impaired pancreatic beta cell function, requiring lifelong insulin injections to control blood sugar) and type 2 diabetes (can be treated on the basis of a combination of lifestyle and oral hypoglycemic drugs, such as HbA1c still When it is greater than 7.0%, insulin therapy can be considered). If patients use insulin injections to control blood sugar, there will be many potential complications. The most common is brain damage caused by hypoglycemia, which will cause great harm to the patient.

Relevant scientific research shows that for brain damage caused by hypoglycemia, taking NMN can improve neuronal damage and cognitive impairment caused by severe hypoglycemia, and also alleviate spatial learning and memory impairment caused by severe hypoglycemia, which is promising. Becoming a promising therapeutic agent for preventing brain damage caused by hypoglycemia. The researchers published the results in the Brain Research Bulletin.

In this study, researchers found that NMN can reduce neuronal death after severe hypoglycemia. Sick rats treated with injections of glucose and NMN had 83% fewer neuronal deaths than mice that received only glucose. When the researchers gave mice a chemical that produced inactive nicotinamide adenine dinucleotide (NAD+), a molecule downstream of NMN, neuronal death increased by 449%, reversing NMN's protective effects. The results indicate that NAD+ plays an important role in preventing neuronal death.

In severely hypoglycemic rats, NMN not only reduced the formation of ROS and the activation of molecular repair pathways, but also restored the levels of NAD+ and energy molecules. In addition, NMN can prevent spatial learning and memory deficits after severe hypoglycemia.

Taken together, NMN protects the brain from severe hypoglycemia-induced neuronal damage and its associated cognitive deficits, and the application of NMN may be an effective intervention for patients with severe hypoglycemia.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.