The preventive effect of NMN on hearing damage

 

As the population ages, the number of people suffering from hearing loss is gradually increasing, but only a very small number of people will actively seek help and receive hearing solutions. It is precisely because we know little about the causes of hearing loss, its impact on personal life, and how to scientifically prevent and treat it that many people miss early recovery. As hearing loss progresses, treatment becomes more difficult, seriously affecting communication and quality of life.

So what are the causes of hearing loss? Generally, the most common causes are long-term exposure to the vocal environment and aging, as well as other factors such as genetics, disease, infection, and drug treatment.

In recent years, scientific researchers have conducted long-term and large-scale animal and clinical trials on the causes of hearing loss and prevention techniques, as well as the new anti-aging ingredient NMN, hoping to improve the degree of hearing loss. The results were pleasantly surprised to find that NMN has particularly good preventive and therapeutic effects on hearing loss in humans and animals.

1. NMN has therapeutic effects on age-related hearing loss

Age-related hearing loss (ARHL) is a degenerative disease characterized by an age-dependent progressive increase in auditory sensitivity thresholds, mostly affecting people over the age of 65. Various factors, including genetic and environmental components, are known to influence the onset and severity of ARHL. In particular, age-dependent changes in cellular oxidative stress and inflammatory responses, accompanied by changes in cell signaling and gene expression, gradually affect the function of the auditory system and ultimately lead to hearing impairment.

In 2020, researchers studied the relationship between NAD+ levels and deafness in CS (patient-derived fibroblast) animal models. Experimental results show that nicotinamide adenine dinucleotide (NAD+) levels are low in CS cells and mice, and that brief intervention (only 10 days) by injecting NAD+ precursors can rescue progressive high-frequency hearing loss.

2.NMN can prevent and treat noise-induced hearing loss

Noise exposure is the leading cause of hearing loss worldwide. Under intense noise exposure, hair cells release neurotransmitter molecules that disrupt the connections between cochlear hair cells and afferent nerves. Continued noise exposure can lead to permanent damage to these structures as well as permanent hearing loss.

Cornell University scientist Professor Samie R. Jaffery and colleagues found that injecting mice with NAD+ precursors can activate SIRT3 (a protein that prevents damage to the neural connections between the ear and the brain) in cochlear cells. ), indicating that supplementing NAD+ precursors after exposure to noise is sufficient to prevent temporary and permanent hearing loss and exert a hearing protective effect.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.