Heart failure (referred to as heart failure) is the leading cause of death from cardiovascular disease. However, heart failure is not an independent disease, but a common result of a variety of heart diseases. Almost all cardiovascular diseases will eventually lead to heart failure, such as cardiomyopathy, myocardial infarction, coronary heart disease, hypertension, diabetes, pulmonary heart disease, valvular disease, etc.
In short, these diseases will increase the burden on the heart, and the heart must beat harder to ensure blood supply to the whole body and meet the metabolic needs of the body. Due to the long-term "overload" work of the heart, it gradually changes from "effort to compensate" to "powerless", inducing heart failure.
In past studies, NMN has performed well in improving cardiac function, including protecting the heart from ischemia/reperfusion injury, maintaining cardiac mitochondrial homeostasis, improving the metabolism and function of the aging heart, reducing cardiac fibrosis, etc.
In 2023, researchers from Japan's Kyushu University and Kyoto University published a study in the international journal "Life Science Alliance" showing that NMN can prevent heart failure by improving lysosomal function.
Interactions between lysosomes and mitochondria have been suggested to be required for maintaining cellular homeostasis. Lysosomes contribute to intracellular energy production by producing amino acids, sugars, and lipids. Lysosomes are involved in mitochondrial fission, and mitochondria regulate lysosomal dynamics, where dysfunction in one function affects the other.
By testing the mRNA expression level of Tfeb, a transcription factor that regulates lysosomal biosynthesis, it was found that lysosomal function is impaired with the reduction of NAD+ biosynthesis in the body, while NMN improved lysosomal function and improved autologous The function of phagocytosis.
*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.