The relationship between NAD+ and aging

 

Nicotinamide adenine dinucleotide (NAD+) exists in every cell of our human body. It is a key metabolite and coenzyme in various metabolic pathways. It mediates and participates in various biological processes. More than 300 enzymes rely on NAD+ to work.

NAD+ acts as a shuttle bus, carrying electrons from one cell molecule to another. Together with its molecular counterpart NADH, it participates in various metabolic reactions through electron exchange that produce adenosine triphosphate (ATP), the body's "energy" molecule.

▲NAD+ is involved in various reactions in the human body

The relationship between NAD+ and aging

Coenzymes participate in the metabolism of important substances such as sugar, fat, and protein in the human body, and play a key role in regulating the body's material and energy metabolism and maintaining normal physiological functions. NAD is the most important coenzyme in the human body, also called coenzyme I. It participates in thousands of redox enzymatic reactions in the human body. It is an indispensable substance for the metabolism of every cell. It has many functions, the main functions are:

1. Promote the production of biological energy

NAD+ generates ATP through cellular respiration, directly supplementing cell energy and enhancing cell function;

2. Repair genes

NAD+ is the only substrate for the DNA repair enzyme PARP. This type of enzyme participates in DNA repair, helps repair damaged DNA and cells, reduces the chance of cell mutation, and prevents the occurrence of cancer;

3. Activate all longevity proteins

NAD+ can activate all 7 longevity proteins, so NAD+ has a more important impact on anti-aging and extending lifespan;

4. Strengthen the immune system

NAD+ strengthens the immune system and improves cellular immunity by selectively affecting the survival and function of regulatory T cells.

A large number of studies have shown that increasing NAD+ levels in the body is beneficial to the improvement of a variety of aging-related diseases, including cognitive decline, inflammation, cancer, metabolic diseases, sarcopenia, neurodegenerative diseases, etc.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.