NAD is one of the most important coenzymes in the human body, also called coenzyme I, and its full name is nicotinamide adenine dinucleotide. It exists in the human body in the form of NAD+/NADH (oxidized state/reduced state). NAD is an essential substance in cell metabolism.
Two major features of NAD+
NAD+ is an important component of cellular activity and is involved in energy supply and DNA repair, both of which are closely related to healthy aging.
1. It is widely distributed in all cells of the human body and participates in thousands of biocatalytic reactions. It can promote the metabolism of sugar, fat and amino acids, and participate in the synthesis of energy. It is an essential and important coenzyme for the human body.
2. NAD+ is the only substrate for coenzyme I consuming enzymes (the only substrate for the DNA repair enzyme PARP, the only substrate for the longevity protein Sirtuins, and the only substrate for the cyclic ADP ribose synthase CD38/157). However, as age increases, the level of NAD+ in the body decreases rapidly. It will decrease by 50% every 20 years. At almost 40 years old, the NAD+ content in the human body is only 25% of what it was in children.
The role of NAD+ on the human body
1. Catalysis generates more than 95% of life activity energy
It provides 95% of the body's energy through cellular tricarboxylic acid cycle, fat B oxidation, etc. It plays an essential role in cellular energy metabolism, oxidative stress regulation and signaling pathway transmission.
2. Repair damaged DNA
NAD+ is an essential substrate for the DNA repair enzyme PARP, which has a significant impact on DNA repair, gene expression, cell development, cell survival, chromosome reconstruction, and gene stability.
3. Activate longevity protein
If human cells lack NAD+, mitochondrial dysfunction is reduced, DNA damage repair ability is reduced, the longevity gene protein family Sirtuin is also inactivated, and so on. These negative factors can lead to apoptosis, human disease, aging and even death.
4. Prevent cardiovascular disease
Studies have shown that almost all seven subtypes of sirtuins (SIRT1-SIRT7) are related to the occurrence of cardiovascular disease. Sirtuins are considered to be exciting targets for cardiovascular disease treatment, especially SIRT1.
NAD+ is the only substrate for Sirtuins. Timely supplementation of NAD+ to the human body can fully activate the activity of each subtype of Sirtuins, thereby protecting cardiovascular health and preventing cardiovascular diseases.
*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.