What are the effects of supplementing NAD+ and its precursors on women?
Nicotinamide adenine dinucleotide (NAD+) is an important coenzyme in many physiological processes and also plays an important role in the reproductive system.
Recently, a research team has proven that NAD+ and its precursors show good prospects in reproductive capacity.
As we age, NAD+ levels decrease in reproductive organs such as the ovaries and uterus, but this can be reversed by supplementing NAD+ precursors.
NAD+ can be synthesized in the body through precursors such as nicotinamide riboside and Nicotinamide Mononucleotide.
Since NAD+ is involved in a wide range of biological processes, disruption of NAD+ pools in the reproductive system can have effects on ovarian aging, polycystic ovary syndrome, embryonic development, and tumors.
A large amount of evidence shows that supplementing NAD+ precursors and interfering with NAD+ biosynthesis have an impact on related diseases.
It has beneficial effects and shows great potential in protecting women's health.
By supplementing NAD+ precursors, it improves mitochondrial function, reduces ROS levels, reduces oxidative damage, DNA damage and apoptosis, thereby protecting the ovary.
Studies have proven that NAD+ precursors rescue PCOS by improving insulin resistance, inflammation and mitochondrial function.
This study infers that NAD+ may also have a certain impact on ovarian aging, spontaneous abortion or congenital malformations, and gynecological tumors.
This study reviews the role of NAD+ in female reproductive diseases, emphasizes the protective effect of supplementing NAD+ precursors on fertility and other female-related diseases, and provides a new perspective for female reproductive treatment research.
Pictures and texts come from following documents:
[1] Li L, Zhou X, Liu W, et al. Supplementation with NAD+ and its precursors: A rescue of female reproductive diseases[J]. Biochemistry and Biophysics Reports, 2024, 38: 101715.
*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.
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