What are the effects of supplementing NAD+ and its precursors on women?

 

Nicotinamide adenine dinucleotide (NAD+) is an important coenzyme in many physiological processes and also plays an important role in the reproductive system.

Recently, a research team has proven that NAD+ and its precursors show good prospects in reproductive capacity. As we age, NAD+ levels decrease in reproductive organs such as the ovaries and uterus, but this can be reversed by supplementing NAD+ precursors. NAD+ can be synthesized in the body through precursors such as nicotinamide riboside and Nicotinamide Mononucleotide.

Since NAD+ is involved in a wide range of biological processes, disruption of NAD+ pools in the reproductive system can have effects on ovarian aging, polycystic ovary syndrome, embryonic development, and tumors. A large amount of evidence shows that supplementing NAD+ precursors and interfering with NAD+ biosynthesis have an impact on related diseases. It has beneficial effects and shows great potential in protecting women's health.

By supplementing NAD+ precursors, it improves mitochondrial function, reduces ROS levels, reduces oxidative damage, DNA damage and apoptosis, thereby protecting the ovary.

Studies have proven that NAD+ precursors rescue PCOS by improving insulin resistance, inflammation and mitochondrial function.

This study infers that NAD+ may also have a certain impact on ovarian aging, spontaneous abortion or congenital malformations, and gynecological tumors.

This study reviews the role of NAD+ in female reproductive diseases, emphasizes the protective effect of supplementing NAD+ precursors on fertility and other female-related diseases, and provides a new perspective for female reproductive treatment research.

Pictures and texts come from the following documents:

[1] Li L, Zhou X, Liu W, et al. Supplementation with NAD+ and its precursors: A rescue of female reproductive diseases[J]. Biochemistry and Biophysics Reports, 2024, 38: 101715.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.