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Why enhance NAD+?

Author: China Glutathione suppliers & manufacturers Release time: 2024-02-19 Column: Product News


Coenzyme I (NAD+), also known as nicotinamide adenine dinucleotide. In 1904, Nobel Prize winner Sir Arthur Harden first discovered the existence of coenzyme I during yeast fermentation. This is the first coenzyme substance discovered in human history. After a century of repeated demonstrations, NAD+ has become a core metabolite in the field of anti-aging, playing an important role in many physiological processes such as metabolism, DNA repair, chromatin remodeling, cell aging and immunity.


1.What functions does NAD+ have?

NAD+ has emerged as a key regulator of cell signaling and cell survival. Recent studies have shown that sirtuins catalyze a variety of NAD+-dependent reactions, including deacetylation, deacylation, and ADP-ribosylation. The catalytic activity of Sirtuins depends on the level of NAD+.

Functional applications of NAD+:

1. Promote the production of bioenergy

2. Improve chromosome stability

3. Strengthen the immune system

4. Repair damaged DNA

5. Activate longevity factors

6. Neurotransmitters

2. Why enhance NAD+?

As age increases, the NAD+ content in the human body decreases, causing a series of pathologies of comprehensive metabolic disorders. Supplementing NAD+ precursors or promoting NAD+ production can significantly alleviate the occurrence of aging, neurodegeneration, diabetes and tumors. Therefore, exogenous It is necessary to supplement NAD+. Different NAD+ enhancement strategies have been proven to be effective in extending healthy lifespan. 

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Therefore, using NAD+ precursors such as NMN and NR to promote NAD+ biosynthesis or inhibit NAD+ degradation provides a new method to extend human healthy lifespan and is an effective anti-aging intervention. measures to bring hope to the global aging society.

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[1] Yang Min, Weng Pingping, Yang Xinwei, et al. Progress in synthesis and functional research of nicotinamide adenine dinucleotide [J]. Biochemical Engineering, 2023, 9(06): 156-164.

[2] Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021 Feb;22(2):119-141. doi: 10.1038/s41580- 020-00313-x. Epub 2020 Dec 22. PMID: 33353981; PMCID: PMC7963035.

[3] Liu Shuai, Peng Liangyu, Xu Jiyan, etc. Research progress of nicotinamide adenine dinucleotide in circadian rhythm disorders [J]. Journal of Clinical Anesthesiology, 2023, 39(02): 178-182.

[4] Bai Yujie, Wang Jianhui, Wu Dongying. The role of nicotinamide adenine dinucleotide and Sirtuins in aging and disease [J]. Chinese Journal of Biochemistry and Molecular Biology, 2022, 38(10): 1294-1303. DOI:10.13865/j.cnki.cjbmb.2022.04.1562.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.


Tag: NMN , NAD , NR

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