PQQ and NMN: Extra Support for Daily Bodily Nutrition

by: Weber Liu Time: 2026-08-19 Classify: Product News

Accelerated modern lifestyles mean physical exercise and daily work both impose metabolic stress on the body.

A growing number of people are turning their attention to cellular-level dietary nutritional supplementation.

Pyrroloquinoline quinone (PQQ) and nicotinamide mononucleotide (NMN), well-researched nutritional raw materials widely studied in the scientific community, have become common daily nutrition choices for many people thanks to their unique physiological functions.

Physiological Functions of PQQ

PQQ is a vitamin-like coenzyme that the human body cannot synthesize on its own.

It has diverse biological potential including antioxidant activity and neurotrophic support.

It activates the Nrf2/ARE antioxidant pathway to help the body counteract oxidative burden.

Meanwhile, it upregulates the expression of nerve growth factor to support neuronal maintenance.

It can also activate the AMPK/PGC-1α and SIRT1 pathways to sustain mitochondrial function and provide nutritional support for cellular energy metabolism.

Physiological Functions of NMN

As a precursor to NAD⁺, NMN supplementation helps raise endogenous NAD⁺ levels.

NAD⁺ participates in a wide range of fundamental human physiological processes.

Via the SIRT1 pathway, it helps maintain mitochondrial biogenesis, supports neuronal health, eases bodily oxidative stress, and lays a nutritional foundation for cellular homeostasis.

Complementary Effects of the Two Substances

Their signaling pathways complement each other:

PQQ tends to directly trigger antioxidant and neuroprotective signals, while NMN focuses on supplying substrates to sustain the function of SIRT1-related pathways.

Combined supplementation may deliver synergistic nutritional benefits and jointly stabilize bodily function under physiological stress.

A randomized, double-blind, controlled study published in Scientific Reports investigated these two ingredients.

The research found that PQQ supplementation before exercise improved interoceptive performance — the ability of "listening to one's body" — helping individuals better perceive internal bodily signals.

Combined PQQ and NMN supplementation also showed potential synergistic stabilizing effects on bodily interoception during exercise, offering new insights into dietary nutrition strategies for active populations.

It should be noted that this experiment examined single-dose acute supplementation;

further research is required to explore its long-term benefits.

Whether you enjoy sports, face daily metabolic strain, maintain a busy schedule, or aim for refined personal nutrition management, PQQ and NMN can serve as dietary supplement options.

Scientific supplementation is not a replacement for a healthy lifestyle;

balanced diets and regular rest remain the foundation of wellness.

Reference

Zhao C, Wu B, Sui H, et al. The effects of pyrroloquinoline quinone and nicotinamide mononucleotide supplementation on interoception following acute exhaustive exercise: a randomised, double-blind, placebo-controlled study[J]. Scientific Reports, 2026, 16:5408.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.