ATP - the energy base for sustaining life

 

The energy basis of life is a molecule called adenosine triphosphate (C10H16N5O13P3), which is a high-energy compound composed of ribose, adenine and three phosphate groups connected. Life activities are the most direct source of energy for living organisms. When cells need energy, such as to expel molecules or repair functions, cells break it down and use chemical energy to work or produce changes, which organisms use to keep internal skills running, which is essential to every life process. important.

In order to facilitate the absorption, transportation and elimination of the human body, most of the medicinal adenosine triphosphate on the market exists in the form of sodium salt, that is, adenosine triphosphate disodium (C10H14N5Na2O13P3), for the convenience of understanding, hereinafter collectively referred to as ATP.

ATP is the direct source of energy for life activities. Almost all the energy needed by the human body is provided by ATP: the beating of the heart, the movement of muscles, and various functions of various cells are derived from the energy generated by ATP. Without ATP, various organs and tissues of the human body will strike one after another, resulting in heart failure, muscle soft pain, and easy fatigue.

When ATP synthesis is insufficient, the human body will feel weak, and there will be cardiac dysfunction, muscle pain, and limb stiffness. If the synthesis of ATP is insufficient for a long time, the tissues and organs of the body will partially or completely lose their functions. For humans, the most affected tissues and organs are the heart and skeletal muscle. Therefore, ensuring the timely synthesis of ATP in cardiac and skeletal muscle cells is an important measure to maintain cardiac and muscle function.

paroxysmal supraventricular tachycardia

Paroxysmal supraventricular tachycardia is one of the common clinical arrhythmias. In order to stop its onset, the current clinical treatment plan is mainly drug conversion. The prevalence rate of ATP is as high as 2.29/1 000 in patients with schizophrenia and in healthy people. After ATP enters the body, it inhibits calcium channels and is rapidly converted into adenosine by enzymatic hydrolysis and binds to adenosine A1 receptors in the atrioventricular node. Inducing negative conduction in the atrioventricular node, it can effectively terminate the reentrant tachycardia involving the atrioventricular node. It has the advantages of short cardioversion time and high conversion rate. It is clinically used for the treatment of paroxysmal supraventricular cardiac One of the most widely used drugs for overdose.

ATP treatment of supraventricular tachycardia has been reported as early as 1955. ATP is often used as a disodium salt for medicinal purposes, and freeze-dried powder injection and water injection are the common dosage forms.

Adenosine triphosphate disodium injection (Sinopharm)

It is used for the adjuvant treatment of progressive muscular atrophy, sequelae of cerebral hemorrhage, cardiac insufficiency, heart disease and hepatitis.

ATP is currently widely used in clinical medical research, food and other fields. Pure ATP is in the form of white powder and can be dissolved in water. As a drug that can directly provide energy and improve the patient's metabolism, ATP tablets can be taken orally, and injections can be injected intramuscularly or intravenously.

Disodium Adenosine Triphosphate Tablets (Baiyun Mountain)

It is used for the adjuvant treatment of progressive muscular atrophy, sequelae of cerebral hemorrhage, cardiac insufficiency, heart disease and hepatitis.

Adenosine Triphosphate Disodium Tablets (Kangfuding)

It is used for the adjuvant treatment of progressive muscular atrophy, sequelae of cerebral hemorrhage, cardiac insufficiency, heart disease and hepatitis.

Adenosine triphosphate disodium injection (Nanguo)

It is used for the adjuvant treatment of progressive muscular atrophy, sequelae of cerebral hemorrhage, cardiac insufficiency, heart disease and hepatitis.

ATP is ubiquitous in all living organisms and is used to store and transfer chemical energy, known as "energy currency". When the organism dies, ATP is quickly broken down under the action of intracellular enzymes. Therefore, the number of viable cells can be estimated by measuring the ATP concentration in the sample.

ATP bioluminescence is a simplified biochemical method that uses the reaction of ATP with a luciferin-luciferase complex to determine the presence or absence of ATP. This method can quantify the content of microorganisms in food raw materials, meat, aquatic products, vegetables, beverages, wine, yogurt, etc.

In addition, ATP is often used as an indicator of microbial contamination, and the detection of ATP content can directly reflect the degree of contamination. Determination of the level of ATP and its dynamic changes in organisms has become an indispensable means of monitoring organisms.

In the early days, ATP was mainly extracted from the muscle tissue of animals, and was later produced by chemical synthesis and photophosphorylation. ATP synthesis method for catalytically active substances; around the 1980s, the method of producing ATP by immobilized enzyme/cell method began to appear.

In the early 1960s, my country began to use spinach leaf photosynthetic phosphorylation and other methods to produce ATP, and the cost has always been high. At present, ATP production in the domestic market is mainly synthesized by yeast glycolysis, and a large number of discarded yeasts have relatively large pollution to the atmosphere, water source and soil environment. Gut Bio uses a new type of enzymatic technology, using adenosine as a substrate to synthesize ATP by multi-stage enzymatic reaction, which is easy to purify and greatly reduces pollution.

With the development of enzyme engineering and biochemical technology, the production of pharmaceutical products by enzymatic method using ATP as raw material has reached the scale of industrial application, and the market demand for ATP is increasing day by day.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.