S-adenosyl-L-methionine p-toluenesulfonic acid sulfate (SAMe) is a metabolite of the sulfur-containing amino acid methionine combined with the body's main energy substance adenosine triphosphate. SAMe is neither a herb nor a hormone. It is a particulate molecule. , involved in more than 200 biochemical reactions in the human body.
In the human body, SAMe is an important physiologically active substance. It participates in more than 40 biochemical reactions and is the active precursor of sulfur-containing compounds such as glutathione, cysteine, taurine and coenzyme A.
SAMe’s development history:
1. In the 1970s, SAMe began to be used as a prescription drug to treat arthritis in Europe;
2. In the mid-1980s, SAMe was first recommended as an antidepressant psychiatric drug in Europe;
3. In 1990, SAMe passed FDA’s randomized double-blind verification in the United States;
4. In 1996, the FDA officially approved SAMe’s enteric solvents and capsules as over-the-counter (OTC) drugs, which expanded its clinical application;
5. In 1999, the FDA approved SAMe as a health product, and it quickly became one of the best-selling nutritional health products.
SAMe has different application focuses in different countries: in Europe and the United States, it is widely used as an antidepressant drug and health product; while in China, its clinical application is mainly focused on liver disease.
*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.