NMN research on liver

 

Persistent infection with hepatitis B virus (HBV) can lead to chronic liver disease, called chronic hepatitis B. According to the World Health Organization (WHO), there were approximately 1.5 million new HBV infections, 296 million chronic infections, and 820,000 deaths from liver failure, cirrhosis, or hepatocellular carcinoma related to HBV infection in 2019. disease.

In previous studies, NMN has been proven many times to have a protective effect on the liver, including relieving hangover and protecting the liver (improving alcoholic fatty liver disease), reducing liver oxidative stress, and improving protein acetylation in aging livers. In this study by Italian scientists, in addition to NMN continuing to exert its "hepatoprotective" effect, another role that cannot be ignored is CD38.

CD38 is a protein that exists on immune cells. Multiple studies have proven that the decrease in NAD+ levels with age is due to the overactivity of CD38.

A 2023 study published in the "Journal of Hepatol" by the University of Parma, Italy, found that in chronic hepatitis B infection, increased levels of reactive oxygen species (ROS) caused by mitochondrial dysfunction can lead to specific CD8 T cells (which play an important role in clearing hepatitis B virus). Lymphocytes) increased DNA damage. This is related to CD38 accelerating NAD+ consumption. Both supplementing NMN and inhibiting CD38 activity can restore specific CD8 T cell function.

Reference: Paola Fisicaro, Carlo Ferrari, et al. Deregulated intracellular pathways define novel molecular targets for HBV-specific CD8 T cell reconstitution in chronic hepatitis B. J Hepatol. 2023 Mar 7;S0168-8278(23)00167-8.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.