Inflammation is not far away from people's lives. Redness, swelling, and heat are what people usually call "inflammation." It is a defensive response of the body to harmful stimuli. Latest research shows that inflammation is closely related to tumor proliferation and migration as well as many other diseases. For inflammation, NMN may be a very effective solution.
Experiments have shown that the use of NMN can inhibit adipose tissue inflammation in mice. NAD+ levels in macrophages decrease during inflammation, but NMN supplementation can restore NAD+.
Long-term use of NMN products can reduce levels of inflammatory markers. For example, in a study of elderly mice, levels of the inflammatory cytokines IL-6 and TNF-alpha were significantly reduced after 8 weeks of supplementation with NMN products. These pro-inflammatory cytokines rise with age and age-related diseases, so reducing these pro-inflammatory cytokines can reduce the effects of inflammation.
In the same study, NMN products increased levels of the anti-inflammatory cytokines IL-10 and antimicrobial peptides (AMPs), which help regulate immune responses. Through these effects on inflammatory factors, NMN product supplementation helps enhance immune function and the ability to fight inflammation in aged mice.
In 2021, researchers from Tsinghua University published a study on NMN's resistance to inflammation in the well-known molecular biology journal "Frontiers in Molecular Biosciences". Inflammation will change the levels of macrophage metabolites, including NAD+.
NAD+ levels are much higher in healthy macrophages (blue box) than under inflammatory conditions (red box). Treatment of murine phagocytes under inflammatory conditions with NMN increases NAD+ levels (black box), thereby restoring levels of inflammation-related proteins and reversing metabolite changes that occur due to inflammation. Moreover, NMN can also inhibit the levels of a sensory enzyme (COX-2) that causes inflammation and pain, thereby reducing the risk of inflammation. In other words, NMN can inhibit inflammation and reduce damage to the body through multiple pathways.
If you have chronic inflammation, such as gastroenteritis, hepatitis, pancreatitis, cervicitis, etc., or have basic diseases such as insulin resistance, cardiovascular and cerebrovascular diseases, brain aging, etc., oral NMN is a good choice. By supplementing NMN in time, Increasing the NAD+ level in the body is the key to anti-aging, anti-inflammation, and disease prevention. NMN can effectively prevent and improve a variety of diseases.