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How much potential does PQQ have?

Author: China Glutathione suppliers & manufacturers Release time: 2024-03-04 Column: Product News


Pyrroloquinoline Quinone disodium salt, referred to as PQQ, is a coenzyme of oxidoreductase and naturally exists in a variety of foods such as milk, eggs, spinach, etc. In the United States, PQQ is managed as a "generally recognized as safe substance (GRAS)" and can be used as an ingredient in energy drinks, sports drinks, electrolyte drinks and other foods; in the European Union and CaNADa, it is used as a dietary supplement or natural health food.

1. How strong is the antioxidant capacity of PQQ?

PQQ is a redox cycle planar orthoquinone. In its reduced form, PQQ's aryloxy radical scavenging activity is 7.4 times that of vitamin C. Water-soluble PQQ is the most active antioxidant.

It is a natural antioxidant with antioxidant and anti-aging effects, and also plays a powerful role in cardiovascular health, brain health, metabolic health, etc.


2.What functions does PQQ have?

①Helps maintain cellular NAD+ levels and mitochondrial production

PQQ acts as lactate and cofactor during the oxidation of NADH to NAD+, maintaining mitochondrial genesis.

②PQQ stimulates Sirtuin activity

Sirtuins regulate DNA repair and mitochondrial activity. PQQ stimulates protein expression in the Sirtuins enzyme family and maintains NAD+ levels.

③PQQ is very important for ROS defense

PQQ helps maximize ROS defense as a potent redox cycling agent.


In addition to these three major points, studies in recent years have proven that PQQ seems to have neuroprotective effects and can improve memory. Some studies have also shown that PQQ may reduce fat accumulation and improve obesity progression.

PQQ is an important biological factor with strong potential as a nutritional supplement.

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[1] Geng Q, Gao H, Yang R, Guo K, Miao D. Pyrroloquinoline Quinone Prevents Estrogen Deficiency-Induced Osteoporosis by Inhibiting Oxidative Stress and Osteocyte Senescence. Int J Biol Sci. 2019 Jan 1;15(1):58- 68. doi: 10.7150/ijbs.25783. PMID: 30662347; PMCID: PMC6329928.

[2] Jonscher KR, Chowanadisai W, Rucker RB. Pyrroloquinoline-Quinone Is More Than an Antioxidant: A Vitamin-like Accessory Factor Important in Health and Disease Prevention. Biomolecules. 2021 Sep 30;11(10):1441. doi: 10.3390 /biom11101441. PMID: 34680074; PMCID: PMC8533503.

[3] Nakano M, Murayama Y, Hu L, Ikemoto K, Uetake T, Sakatani K. Effects of Antioxidant Supplements (BioPQQ™) on Cerebral Blood Flow and Oxygen Metabolism in the Prefrontal Cortex. Adv Exp Med Biol. 2016;923: 215-222. doi: 10.1007/978-3-319-38810-6_29. PMID: 27526146.

[4] Mohamad Ishak NS, Ikemoto K. Pyrroloquinoline-quinone to reduce fat accumulation and ameliorate obesity progression. Front Mol Biosci. 2023 May 5;10:1200025. doi: 10.3389/fmolb.2023.1200025. PMID: 37214340; PMCID: PMC10196175.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.


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