What does nicotinamide riboside do and is it safe?

 

Nicotinamide riboside (NR) is a form of vitamin B3. As a precursor of NAD+, NR has attracted much attention in recent years.

1.What is the function of NR?

NR is the precursor of NAD+, and its main function is demonstrated through NAD+. As an important coenzyme required for body functions, NAD+ has an impact on metabolism, energy production, regulating the body's circadian rhythm and repairing DNA damage.

①Inhibit neuroinflammation

Numerous animal studies have demonstrated that NR supplementation can increase NAD+ levels and increase anti-inflammatory cytokines to reduce neuroinflammation.

②Anti-aging

Improves physical function in older adults and reduces oxidative stress.

③Reduce the age-related metabolism of hematopoietic stem cells

Improve cell-autonomous metabolism, reduce the pool of stem cells and progenitor cells with increasing age, and improve the reconstruction ability of aging hematopoietic stem cells under steady-state conditions.

The biological functions of NR have received widespread attention, and more and more clinical studies are conducted on metabolic disorders, aging, and neurodegenerative diseases.

2.How should NR be supplemented?

Trace amounts of NR are present in milk and yeast, but the intake is not shown. Currently, the best way to supplement NR is in the form of supplements. NR supplements are available in tablets, capsules and powder forms. The most common dosage is 250mg. However, we do not recommend taking NR without complete knowledge. It is best to consult your healthcare provider for diagnosis, accurate medical information and clearance.

3. Is it safe?

Current research on NR suggests that NR may be safe and well-tolerated. One study evaluated the safety of NR. In an 8-week double-blind trial, NR effectively increased NAD+ levels and did not cause adverse events. .

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references:

[1] Sun Fulton M, Hatwell-Humble J, Das Gupta K, Kapetanovic R, Chen X, Sweet MJ, Parton RG, Ryan MT, Polo JM, Nefzger CM, Nilsson SK. Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells . Nat Commun. 2021 May 11;12(1):2665. doi: 10.1038/s41467-021-22863-0. PMID: 33976125; PMCID: PMC8113506.

[2] Sharma C, Donu D, Cen Y. Emerging Role of Nicotinamide Riboside in Health and Diseases. Nutrients. 2022 Sep 20;14(19):3889. doi: 10.3390/nu14193889. PMID: 36235542; PMCID: PMC9571518.

[3] Roboon J, Hattori T, Ishii H, Takarada-Iemata M, Nguyen DT, Heer CD, O'Meally D, Brenner C, Yamamoto Y, Okamoto H, Higashida H, Hori O. Inhibition of CD38 and supplementation of nicotinamide riboside ameliorate lipopolysaccharide-induced microglial and astrocytic neuroinflammation by increasing NAD. J Neurochem. 2021 Jul;158(2):311-327. doi: 10.1111/jnc.15367. Epub 2021 May 9. PMID: 33871064; PMCID: PMC8282715.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.