NMN increases the growth and migration function of human stem cells, which may contribute to more effective stem cell therapy for various chronic diseases.
NMN enhanced the stem cells' ability to migrate, suggesting they could better target damaged tissue when injected into the body.
Stem cells are hindered by excess reactive oxygen species (ROS), while NMN is reduced.
NMN prevents stem cells from entering a dysfunctional, pro-inflammatory state called senescence.
Stem cells are currently being used clinically to treat degenerative, metabolic and inflammatory diseases. However, as living cells, they lose their ability to locate and repair injured tissue when grown in the lab for too long. For this reason, scientists have been looking for ways to keep stem cells in their highest form in order to maintain their healing effects when infused into the body for therapeutics.
Now, researchers from East China University of Science and Technology in China show that NMN helps maintain the functional lifespan of stem cells in a dish, which could improve the effectiveness of stem cell therapies. NMN can promote stem cell migration, reduce stem cell ROS, and prevent stem cell senescence.
NMN rejuvenates therapeutic stem cells
To study the effect of NMN on stem cells, a type of stem cell called mesenchymal stem cells was used. Umbilical cord stem cells are the most commonly used treatment (after bone marrow stem cells) because they are readily available and do not cause many immune responses when injected into the human body.
Since stem cells need to be treated at injured tissue sites, the researchers tested the effect of NMN on stem cell migration. It was found that NMN could increase the migration of stem cells by 3 times. These findings suggest that NMN can enhance the built-in effect of stem cells in stem cell therapy.
▲NMN enhances stem cell migration
The final results of the experiment show that NMN can prevent stem cell aging and prolong the replicative life of stem cells, increasing the efficacy of stem cell therapy.
Research on strengthening NMN as a support substance for stem cell therapy is currently growing. When it comes to treating age-related chronic diseases, such as heart and brain disorders (primarily degenerative ones), stem cell therapy may only be a matter of time before pharmacological interventions become a thing of the past.