Clinical trial of NMN in healthy men in Japan: NMN is safe and harmless
On January 31, 2022, a clinical trial on healthy Japanese men once again confirmed the safety of taking NMN, which can increase NAD+ levels and significantly improve sleep quality.
At present, NMN plays a quite beneficial role in the existing clinical research, but the effectiveness and safety of intravenous injection of NMN on human body is still unclear. The trial selected 10 healthy volunteers to verify its safety through intravenous injection of NMN. The study assessed NAD+ and SIRT1 activity, fatigue and sleep quality after intravenous administration of NMN.
After intravenous injection of NMN, it does not affect the electrocardiogram, pulse and blood pressure, nor does it affect the metabolic markers of the liver, heart, pancreas and kidney. In addition, the use of NMN can not only significantly increase the NAD+ level in the blood, but also significantly improve the quality of sleep. The findings suggest that intravenous administration of NMN is safe and beneficial for the prevention of aging-related diseases.
On February 11, 2022, the human clinical trial of NMN effect led by the University of Tsukuba in Japan announced the research results. After 12 weeks of intervention, subjects in the 250 mg NMN group had better lower extremity function and significantly less fatigue. It has been confirmed again that NMN can improve fatigue, promote physical function, and improve the physical and mental health of the elderly. The study was published in the journal Nutrients.
The elderly are prone to fatigue, sluggishness, and depression in daily life, and are prone to cognitive impairment and sleep disturbance, resulting in reduced quality of life and increased mortality. Therefore, physical activity, fatigue and sleep quality must be increased from an early stage.
The randomized double-blind controlled method was adopted in the experiment, and a total of 161 elderly people over 65 years old were recruited, 108 of whom met the conditions. Randomly divided into four groups, 27 people in each group, two groups were supplemented with 250mg NMN every day, one group was supplemented in the morning (from getting up to 12 o'clock), the other group was supplemented in the afternoon (from 18 o'clock to bed), and the other two groups were controlled by placebo .
Effects of NMN supplementation or placebo on sleep quality in the four groups
Overall, afternoon intake of NMN effectively improved lower extremity function and reduced lethargy in older adults. These findings suggest that NMN has the potential to prevent and improve fatigue.
At present, a variety of supplemented NMN products have entered the market as dietary supplements or health foods, and there have been no reports of adverse reactions after consumption in many countries and regions.