NAD+ and Aging
A series of energy synthesis and metabolism are going on in the human body all the time to ensure the balance and health of life activities. Nicotinamide adenine dinucleotide (nicotinamide adenine dinucleotide, NAD+), as a coenzyme in the redox reaction process, is an important molecule responsible for energy metabolism. NAD+ directly or indirectly regulates many important cellular functions, including intramitochondrial energy synthesis, DNA damage repair, chromatin remodeling, cellular senescence, and immune cell function. The fundamental physiological processes and functions of these cells are critical for maintaining tissue, metabolic homeostasis, and healthy aging.
Aging is a natural process. As we age, NAD+ levels are gradually depleted in the human body, leading to a downregulation of mitochondrial energy synthesis in various organs, including the brain, adipose tissue, skin, liver, skeletal muscle, and pancreas. Decreased NAD+ levels are causally linked to age-related diseases such as cognitive decline, cancer, metabolic disease, sarcopenia, and frailty. Therefore, targeting NAD+ metabolic pathways to increase NAD+ levels may be a potential means to improve aging-related diseases and extend human lifespan and healthspan.
NMN and anti-aging
As the world ages, there is an increasing demand for anti-aging supplements that can prolong life and delay the onset of age-related diseases. In recent years, NMN has attracted great attention from the scientific community and consumers. In theory, NMN, as a precursor for the synthesis of NAD+, can slow down the process of NAD+ depletion with age by increasing the level of NAD+ in the body, so it can be used as an anti-aging health product.
Furthermore, mitochondrial decay causes aging, and increased NAD+ levels in the body can reverse mitochondrial decay. The scientific community has carried out extensive research on the anti-aging activity of NMN through cell experiments, animal models and clinical trials. There is evidence that NMN can produce beneficial effects in rodent models and human levels, such as protecting endothelial cells, improving blood supply; improving metabolic dysfunction; and protecting the nervous system.
In a randomized double-blind clinical trial in 2021, 25 postmenopausal overweight or obese prediabetic women were treated with oral NMN (250 mg/d) for 10 weeks. Insulin sensitivity.
In a similar study in 2023, 36 healthy adults (40-59 years old, 38.9% male) were treated with oral NMN (250 mg/d) for 12 weeks, and the level of serum nicotinamide (NAD+ metabolite) in the treatment group was significantly higher than that in the placebo group Increased, arterial stiffness index tended to decrease, but there was no statistical difference.
The needs of consumers have driven the emergence of anti-aging health care products, and NMN is currently a commonly used product with anti-aging effects.
It should be emphasized that in addition to supplementing NMN, choosing NMN-rich foods, restricting energy intake and exercising can also increase NAD+ levels in the body, while high-fat diets will reduce NAD+. Therefore, cultivating a good lifestyle and eating habits is the most economical way to fight aging.
*The content of this article comes from the Nutrition Institute of the Chinese Center for Disease Control and Prevention