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With the increasing trend of global population aging, the decline in muscle strength has become an important issue affecting the quality of life of the elderly. The decrease in muscle strength not only affects daily activities but also increases the risk of falls and fractures.
PQQ disodium salt is a compound widely found in a variety of foods and has antioxidant properties. It plays a variety of physiological roles in the human body, including participating in energy metabolism and cell signaling. In recent years, PQQ disodium salt has been in the spotlight for its potential benefits to muscle strength and physical function. A study published in the Journal of Functional Foods has evaluated the efficacy and safety of PQQ disodium salt in healthy volunteers. The results showed that PQQ disodium salt supplements could significantly improve muscle strength and physical function in healthy adults, with no adverse events observed.
In the study, researchers recruited 64 healthy Japanese adults aged 20 to 75, who were randomly divided into two groups, one receiving PQQ disodium salt (21.5 mg/day) and the other receiving a placebo. The study included a 4-week observation period and a 12-week treatment period. The primary endpoint was the muscle strength of the lower limb extensors, and secondary endpoints included grip strength, the 10-meter shuttle walk test, the 6-minute walk test, and the 10-meter walk test. The results showed that at 12 weeks, the muscle strength of the lower limb extensors and grip strength in the PQQ disodium salt group were significantly higher than those in the placebo group and had significantly improved compared to baseline. In addition, the PQQ disodium salt group also performed significantly better in the walking tests, indicating a significant improvement in physical function.
Mechanistically, PQQ disodium salt may work through multiple pathways. First, PQQ disodium salt can activate mitochondrial function, promote energy metabolism, and thus enhance muscle strength. Second, PQQ disodium salt can activate PGC-1α to inhibit muscle protein degradation and maintain muscle mass. In addition, PQQ disodium salt also has antioxidant effects, which can clear free radicals, reduce the damage of oxidative stress to muscle cells, and further promote muscle health.
In summary, as a functional nutrient, PQQ disodium salt has the potential to improve muscle strength and physical function. For adults, especially the elderly, who wish to maintain muscle strength and physical function, PQQ disodium salt may be a supplement worth considering.
Reference:
Shiojima Y, Takahashi M, Takahashi R, et al. Efficacy and safety of Pyrroloquinoline Quinone disodium salt on muscle strength and physical function in healthy volunteers: A randomized, double-blind, placebo-controlled study[J]. Journal of Functional Foods, 2024, 113: 106012.
*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.
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