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Summary of the characteristics of citicoline

Author: GSHWORLD Release time: 2023-08-21 Column: Product News


In the 1950s, Kennedy et al. discovered citicoline, then chemically synthesized it and determined its molecular structure. Rossiter further discovered in 1957 that citicoline is closely related to phospholipid metabolism and is an important coenzyme for the biosynthesis of phosphatidylcholine (lecithin). In 1963, Takeda Corporation of Japan developed and produced Citicoline Sodium, which has been used clinically for many years and has been recognized by many doctors.


Citicoline is a water-soluble compound with over 90% bioavailability. After exogenous citicoline enters the body, it is difficult to pass through the blood-brain barrier, and it is decomposed into cytidine and choline in the intestinal wall, which can pass through the blood-brain barrier and re-synthesize citicoline in the central nervous system. Exogenous citicoline is widely distributed in the cortex, white matter and central gray matter nuclei, and its elimination is extremely slow, with a small amount of daily excretion through urine, feces and respiratory routes.


1. What are the clinical indications of citicoline?

Citicoline is used to treat neurological sequelae caused by craniocerebral injury or cerebrovascular accident.

2. What is the clinical effect of citicoline?

A large number of clinical application research data show that the curative effect of citicoline sodium is significantly better than that of the placebo group, and has a good curative effect.

3. How safe is citicoline?

Gastrointestinal reactions are occasionally seen with citicoline sodium, with mild symptoms and short duration.

A Korean study showed that the safety of oral citicoline (500-4000 mg/d) was analyzed in 4191 patients with acute ischemic stroke, and 37 adverse reactions were observed in only 31 patients, with an incidence rate of only 0.73% .

4. Summary of the characteristics of citicoline?

1) The drug has good properties and is an endogenous substance in the human body itself;

2) Multi-target joint action, the best choice for single drug or combined drug;

3) It has been used clinically for many years and has been recognized by many doctors;

4) It has definite curative effect and is convenient to take, and it is the neuroprotective agent with the strongest evidence in evidence-based medicine;

5) It can be used in multiple clinical departments, and can be applied to many central nervous system diseases;

6) High bioavailability, long-term use will benefit more;

7) High safety, no significant systemic cholinergic effect, good tolerance, almost no adverse reactions;

8) High pharmacoeconomic value.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.

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