Cognitive function consists of multiple cognitive domains, including memory, computation, spatio-temporal orientation, structural abilities, executive abilities, language, comprehension, expression, and application. Cerebral atherosclerotic stenosis is an important pathological basis of ischemic cerebrovascular disease. Most of the current studies have confirmed that carotid artery stenosis is closely related to cognitive dysfunction, and the reduction of cerebral blood flow is an important reason for and promotes cognitive decline.
Cerebrovascular stenosis is closely related to cognitive function, and the degree of impairment of cognitive function is positively correlated with the degree of vascular stenosis. It mainly manifests as damage to memory (including visual and verbal memory), attention, and structural ability; but it has less adverse effects on functions such as executive ability and information processing speed, which is related to the fact that the main blood supply area is the hippocampus. The hippocampal region of the brain is considered to be closely related to cognitive functions, not only playing an important role in language, emotion and neuropsychological activities, but also mainly involved in cognitive activities such as memory, learning and language. Long-term cerebral ischemia can lead to disorders of phospholipid metabolism in the membrane of hippocampal neurons, excessive production of free radicals, release of excitatory amino groups, and overload of intracellular calcium ions, etc., eventually leading to neurotransmitter disorders and neuron loss in the hippocampus, and thus may lead to cognitive impairment.
Citicoline Sodium is a nucleoside derivative, which can enhance the brainstem reticular structure, especially the function of the ascending reticular structure activation system closely related to consciousness, increase the function of the pyramidal system, improve motor paralysis, and improve brain circulation. Reduce the resistance of cerebral blood flow, increase cerebral blood flow and promote brain substance metabolism, which has a certain effect on promoting the recovery of brain function.
Studies have shown that citicoline sodium and diacylglycerol are catalyzed by enzymes to generate phosphatidylcholine. The latter builds a bilayer lipid membrane, so citicoline sodium tablets can repair nerve cell membranes and regenerate neurons. Citicoline Sodium Tablets inhibit the release of arachidonic acid through the inhibition of phospholipase, reduce the production of oxidative molecules, free radicals and neurotoxic substances, and avoid nerve cell apoptosis.
Based on the above theoretical basis, some researchers explored the relationship between patients with middle cerebral artery stenosis and changes in cognitive function, and treated the patients with citicoline sodium tablets for 12 weeks to observe its curative effect. The results showed that after 12 weeks of treatment with Citicoline Sodium Tablets, the scores of verbal memory, visual memory, executive ability and structural ability in the stenotic infarction group were significantly higher than those before treatment.
Patients with middle cerebral artery stenosis have different degrees of cognitive impairment before or after cerebral infarction, and citicoline sodium tablets can improve cognitive impairment.