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Sedentary for long periods of time without exercise, excessive intake of foods high in oil and salt, and a variety of sweets and drinks. These lifestyle habits are potential factors leading to obesity. Many people will suffer from emotional anxiety due to obesity, and excessive Obesity can also cause some health problems.
Moderate exercise and a healthy diet are the keys to preventing obesity. In order to prevent obesity and obesity-related diseases, researchers have long been studying dietary ingredients that can prevent obesity.
PQQ is found in many dietary sources, including tea, green peppers, parsley, kiwi fruit, etc., and studies have shown that supplementing with PQQ may help prevent obesity by inhibiting fat accumulation in the body.
In a study, researchers explored the dietary effect mechanism of PQQ in inhibiting fat accumulation in the body. The researchers induced obesity by giving 10 male mice a high-fat diet (HFD), and added PQQ to the HFD feed of some mice. 0.02% PQQ, control mice were fed a normal diet (ND). After 6 weeks, although PQQ failed to protect the mice from weight gain caused by HFD, they weighed less and looked thinner than mice fed HFD alone.
These results indicate that PQQ can inhibit the accumulation of body fat caused by obesity, especially the accumulation of visceral fat.
NMN has always attracted attention for its potential anti-aging functions. Studies have proven that NMN can effectively inhibit aging-related weight gain, enhance energy metabolism, and promote physical activity.
Researchers studied the direct effects of Nicotinamide Mononucleotide (NMN) on lipid metabolism in adipocytes, specifically in inducing lipolysis. In obese mice fed a high-fat diet, NMN treatment significantly reduced subcutaneous fat mass and reduced adipocyte size. Studies have shown that NMN induces lipolysis in adipocytes by increasing ATGL expression through the SIRT1-AMPK axis. This may provide new targets for the treatment of obesity and related metabolic diseases.
[1] Mohamad Ishak N S, Ikemoto K, Kikuchi M, et al. Pyrroloquinoline Quinone attenuates fat accumulation in obese mice fed with a high-fat diet, Daphnia magna supplied with a high amount of food, and 3T3-L1 adipocytes[J] . ACS Food Science & Technology, 2021, 1(10): 1979-1989.
[2] Imi Y, Amano R, Kasahara N, et al. Nicotinamide mononucleotide induces lipolysis by regulating ATGL expression via the SIRT1-AMPK axis in adipocytes[J]. Biochemistry and Biophysics Reports, 2023, 34: 101476.
*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.
