Why should we supplement NAD+ precursors?

 

Nicotinamide adenine dinucleotide (NAD+) is coenzyme I. It is a kind of electron transfer and a coenzyme of many dehydrogenases in the body. It connects the tricarboxylic acid cycle and the respiratory chain. Its function is to transfer the hydrogen taken off during metabolism to flavoprotein. NADH or more accurately NADH with H+ is its reduced form.

NAD+ was originally discovered to be an important part of the process that delivers chemical energy from food into the ATP fuel that cells need. Recent research shows that NAD + itself is an "energy currency" similar to ATP, a complex organic chemical that provides energy to drive many processes in living cells.

NAD+ is also a functional signaling molecule in processes related to energy production, including PARP-1 and Sirtuin. When DNA damage occurs, PARP-1 consumes large amounts of NAD+, resulting in reduced energy production. Additionally, high levels of NAD+ activate sirtuin proteins, enabling them to carry out metabolic and stress-protective responses and contribute to longevity.

People can increase the level of NAD+ in the body through several ways of supplementing NAD+ precursor substances. Existing research data shows that NAD+ has a total of 5 precursors: NMN (Nicotinamide Mononucleotide), NA (nicotinic acid), NAM (nicotinamide), NR (nicotinamide ribose), and Trp (tryptophan). Substance that can be converted into NAD+.

By supplementing NAD+ precursors, the biosynthesis of NAD+ can be increased, thereby increasing the NAD+ level in the body. Therefore, NAD+ precursor supplementation also represents a potential therapeutic strategy to slow down aging and ameliorate age-related diseases.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.