Effects of ATP Supplementation on Healthy Resistance-Trained Individuals

by: GSHWORLD Time: 2026-02-06 Classify: Product News

As the core energy molecule in the human body, ATP plays a crucial role in muscle contraction and relaxation processes.

It releases energy through hydrolysis into ADP and inorganic phosphate, driving sarcomere sliding to achieve muscle contraction, while also participating in calcium ion transport to facilitate muscle recovery and relaxation.

Furthermore, ATP serves as an important signaling molecule that can bind to purinergic receptors on vascular endothelium, promoting vasodilation and enhancing oxygen and nutrient supply to muscle tissue.

For resistance-trained individuals, high-intensity exercise easily induces muscle hypoxia, while ATP can alleviate hypoxic stress through synthesis and release by red blood cells, providing support for sustained muscle force production.

Strength Performance Enhancement

ATP supplementation significantly improves maximal muscular strength in healthy resistance-trained individuals.

Clinical studies have confirmed that compared to placebo groups, ATP supplementation groups achieve more pronounced strength gains in core resistance exercises such as bench press and squat.

This effect stems from ATP's multiple regulatory effects on muscle function:

on one hand, it optimizes muscle contraction efficiency and enhances synergistic working capacity of muscle fibers;

on the other hand, it improves local blood circulation, reduces lactate accumulation during exercise, and delays muscle fatigue.

Individuals who persist in long-term resistance training have higher demands for energy supply in their muscle tissue, and ATP supplementation can precisely compensate for energy depletion during exercise, helping to break through strength plateaus.

Effects on Other Parameters

Regarding maximum repetition performance and anaerobic power, ATP supplementation has not demonstrated significant improvement effects.

Analysis suggests this is related to factors such as exercise testing protocols and training intensity.

Performance in resistance training repetitions depends not only on energy supply but also involves multiple aspects including muscular endurance and neural regulation;

single supplementation of ATP is difficult to produce decisive effects. Moreover, anaerobic power tests typically involve short-duration explosive exercises, for which endogenous ATP reserves in the body are already sufficient to meet demands, leaving limited room for gains from exogenous supplementation.

However, it should be noted that some studies suggest ATP may have positive effects on muscle excitability during exercise, though this has not yet translated into quantifiable performance improvements.

Safety and Application Prospects

ATP supplementation demonstrates favorable safety in healthy resistance-trained populations.

Multiple clinical studies have shown that neither short-term single supplementation nor long-term regular intake produces significant adverse reactions, nor does it negatively affect blood biochemical indicators.

As a substance naturally present in the human body, ATP supplementation exhibits better tolerability than many synthetic sports supplements.

In the future, with the standardization of research methodologies, its application value in different training scenarios is expected to be further clarified.

For resistance-trained individuals pursuing strength gains, ATP supplementation can serve as a safe auxiliary option, combined with scientific training protocols, to optimize athletic performance.

References:

González-Marenco R, Estrada-Sánchez I A, Medina-Escobedo M, et al. The effect of Oral adenosine triphosphate (ATP) supplementation on anaerobic exercise in healthy resistance-trained individuals: a systematic review and Meta-analysis[J]. Sports, 2024, 12(3): 82.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.