Beneficial Effects of PQQ Supplementation Across Different Age Groups

by: GSHWORLD Time: 2026-02-04 Classify: Product News

Cognitive function is central to maintaining quality of life—from efficient thinking in young adults to memory preservation in older adults, it is closely linked to both physical and mental well-being.

Pyrroloquinoline quinone disodium salt (PQQ), a functional ingredient produced through fermentation and purification, has been approved for use in multiple countries, and its cognitive benefits are attracting widespread attention.

Recent clinical studies indicate that this functional ingredient is not exclusive to any particular age group; rather, it offers targeted cognitive enhancement for people across different life stages.

Young Adults (Ages 20-40)

For young adults between 20 and 40 years old, cognitive flexibility, information processing efficiency, and executive speed are critical abilities for daily learning and work.

Research has found that after PQQ supplementation, young adults can experience improvements in cognitive performance within a short period.

This demographic has robust metabolic activity, and PQQ aligns well with the physiological characteristics of young people by promoting mitochondrial biogenesis and exerting antioxidant activity.

Whether tackling complex work tasks, switching between multiple learning objectives, or improving everyday decision-making efficiency, the cognitive optimization provided by PQQ offers tangible support.

This is especially relevant for young individuals facing attention challenges, as the improvement in cognitive flexibility holds particular practical significance.

Middle-Aged and Older Adults (Ages 41-65)

Among middle-aged and older adults aged 41 to 65, memory decline is the most prominent cognitive concern.

Clinical data show that PQQ supplementation in this population leads to significant improvements in composite memory and verbal memory.

As people age, cognitive function naturally changes, and the abilities to store and retrieve memory face increasing challenges.

The neuroprotective advantages of PQQ become increasingly apparent in this context.

It supports brain nerve cells by enhancing the expression of nerve growth factors, while its antioxidant properties help reduce the impact of oxidative stress on memory function.

These improvements not only help middle-aged and older adults maintain their social engagement and daily self-care abilities but also contribute to delaying cognitive decline.

Middle-Aged and Older Adults (Ages 41-65)

Safety Verification

It is worth noting that the safety of PQQ supplements has been thoroughly validated, with no adverse events observed in clinical studies.

Additionally, its non-GMO status makes it suitable for consumption by diverse populations.

From a mechanistic perspective, the differential improvements across age groups are closely related to physiological characteristics:

young people have active metabolisms, allowing PQQ's mitochondrial activation effects to take effect more rapidly;

middle-aged and older adults, through long-term supplementation, more fully experience its neuroprotective and antioxidant benefits in terms of memory function improvement.

Logistic regression analysis also confirms that as supplementation duration extends, the cognitive benefits of PQQ become more pronounced, and the more refined the age grouping, the more targeted the effects.

Previous research largely focused on middle-aged and elderly populations.

This comprehensive study, spanning ages 20 to 65, is the first to establish PQQ's cognitive enhancement value across all adult age groups.

It breaks through the age limitations of functional cognitive supplements, providing a scientifically grounded health option for people at different life stages.

From boosting work and learning efficiency in young adults to preserving memory function in older adults, PQQ serves as a cognitive health "booster" for all age groups through its targeted beneficial effects.

Looking ahead, as research progresses, the potential value of PQQ in areas such as learning enhancement and athletic performance will be further explored.

However, based on current evidence, existing clinical data have sufficiently demonstrated that as a safe and effective functional ingredient, PQQ can deliver cognitive improvements tailored to the needs of different age groups, offering a novel solution for population-wide cognitive health.

Reference:

Tamakoshi M, Suzuki T, Nishihara E, et al. Pyrroloquinoline quinone disodium salt improves brain function in both younger and older adults[J]. Food & Function, 2023, 14: 2496-2501.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.