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Hair - an important part of the human body. As one of the bonus points of the human body's appearance, it is highly valued by people. However, many factors can cause hair loss. Natural aging, excessive stress, staying up all night, and illness treatment may all lead to hair loss. Therefore, hair loss has become an eternal topic. Minoxidil and finasteride have become effective drugs for promoting hair growth in most patients with androgenetic alopecia. However, possible adverse side effects have also prompted researchers to constantly try to find new bioactive compounds that can stimulate hair growth and drug.
Recently, a research team published a study in the journal Molecules showing that NMN may promote hair growth by promoting blood vessel formation and reducing inflammation.
Cytokines secreted by human dermal cells (HDPCs) play an important role in the hair growth cycle. HDPCs and dihydrotestosterone (DHT) together lead to a decrease in cell viability and the release of inflammatory mediators. Studies have shown that NMN can repair the damage caused by DHT.
▲NMN’s ability to repair DHT-induced damaged HDPC
The mice in the NMN treatment group were compared with the DHT treatment group (negative group), 5% minoxidil treatment group (positive group) and BC group (blank group). After 5 days, mice in the positive group, BC combined with NMN group The mice showed significant hair growth.
▲NMN induces anagen phase in alopecia C57BL/6 mice. Photographs of the back skin were taken at 1, 5, 10 and 15 days after hair removal.
Through research and observation, NMN can effectively improve the impact of DHT on hair. The hair follicles in the NMN group grow faster, are darker in color, and are more numerous.
The results of this study also showed that NMN significantly increased the RNA levels of β-catenin compared with DHT-induced HDPC. The β-catenin signaling pathway plays a crucial role in the development and regeneration of hair follicles, which suggests that NMN may lead to increased β-catenin expression and thereby promote hair growth in mice.
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[1] Xu C, Dai J, Ai H, Du W, Ji H. β-Nicotinamide Mononucleotide Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress. Molecules. 2024 Feb 8;29(4):798. doi: 10.3390/ molecules29040798. PMID: 38398550; PMCID: PMC10893548.
*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.
