NMN or NR?

 

Many studies have shown that health and aging are closely related to NAD+ and its related metabolites. During the aging process, NAD+ levels decrease and DNA damage increases. NR and NMN, as precursors of NAD+, have been the targets of many clinical studies to combat DNA damage and improve aging. , current research proves that NMN and NR can alleviate physiological decline, protect neuronal cells from oxidative stress, and maintain beneficial activities such as cognitive, anti-inflammatory, cardiovascular protection, and health promotion.

There are also studies proving that NMN and NR can prevent endogenous or exogenous-induced DNA damage. Recently, some researchers have systematically compared the effects of NMN and NR on DNA damage.

Same point:

1. Both NMN and NR reduce induced DNA damage in a dose-dependent manner.

▲NMN and NR can rescue the cell viability of cisplatin-treated cells.

2. NMN and NR have similar DNA repair effects

The study compared the effects of NMN and NR on the repair of damaged DNA. The results showed that there was no difference between the NMN and NR treatment groups, and both had similar effects on promoting the repair of damaged DNA.

▲NMN and NR promote the repair of cisplatin-treated DNA damage.

3. Both NMN and NR can increase intracellular NAD+ levels

▲NMN and NR increase intracellular NAD + levels and decrease ROS levels in cisplatin-treated cells.

difference:

1. Compared with NR, NMN is a more direct precursor of NAD+

Although both are precursors of NAD+ and can effectively enhance NAD+ biosynthesis, NR needs to be converted into NMN by nicotinamide riboside kinase and then converted into NAD+ by NMN adenylyltransferase in the body. NMN has a higher absorption rate and higher bioavailability than NR, and is also more stable during manufacturing, transportation and storage.

2.NR exhibits a better protective effect against cisplatin-induced DNA damage than NMN.

NR is relatively a more mature dietary supplement ingredient with better tolerability and pharmacodynamic properties.

In general, both NMN and NR show great potential in healthy aging and certain aging-related diseases.

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references:

[1] Qiu S, Shao S, Zhang Y, Zhang Y, Yin J, Hong Y, Yang J, Tan X, Di C. Comparison of protective effects of nicotinamide mononucleotide and nicotinamide riboside on DNA damage induced by cisplatin in HeLa cells. Biochem Biophys Rep. 2024 Feb 6;37:101655. doi: 10.1016/j.bbrep.2024.101655. PMID: 38333051; PMCID: PMC10851195.

[2] Yoshino J, Baur JA, Imai SI. NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metab. 2018 Mar 6;27(3):513-528. doi: 10.1016/j.cmet.2017.11 .002. Epub 2017 Dec 14. PMID: 29249689; PMCID: PMC5842119.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.