Can NMN supplementation directly affect motor neurons?

 

Recently, a study published in the journal Antioxid Redox Signal showed that Nicotinamide Mononucleotide (NMN) may directly act on motor neurons.

The research team studied the neuroprotective effect of NMN on patients and mouse models of amyotrophic lateral sclerosis (ALS). The results showed that NMN supplementation not only increased the complexity and viability of motor neurons, but also prevented neuronal death caused by trophic factor deficiency.

Experiments have shown that supplementation with NAD+ precursors has a direct beneficial effect on maintaining motor neuron axons.

Another study also showed that dietary NMN supplementation can enhance movement and NMJ function in ALS patients. In mouse experiments, researchers found that dietary supplementation with NMN can slow down movement disorders, improve NMJ morphology, innervation, mitochondrial structure and extend the lifespan of mice.

Nicotinamide mononucleotide (NMN) is a precursor for NAD+ biosynthesis. In vivo/in vitro studies have shown that supplementation with NMN increases NAD+ concentrations and reduces oxidative stress, DNA damage, neurodegenerative diseases and inflammatory responses. Currently, there are more than a dozen human clinical trials on NMN underway around the world, and we look forward to more encouraging results from NMN.

References:

[1] Hamilton HL, Akther M, Anis S, Colwell CB, Vargas MR, Pehar M. NAD+ precursor supplementation modulates neurite complexity and survival in motor neurons from ALS models. Antioxid Redox Signal. 2024 Mar 19. doi: 10.1089/ars.2023.0360. Epub ahead of print. PMID: 38504592.

[2] Lundt S, Zhang N, Polo-Parada L, Wang X, Ding S. Dietary NMN supplementation enhances motor and NMJ function in ALS. Exp Neurol. 2024 Apr;374:114698. doi: 10.1016/j.expneurol.2024.114698. Epub 2024 Jan 22. PMID: 38266764.

[3] Song Q, Zhou X, Xu K, Liu S, Zhu X, Yang J. The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update. Adv Nutr. 2023 Nov;14(6):1416-1435. doi: 10.1016/j.advnut.2023.08.008. Epub 2023 Aug 22. PMID: 37619764; PMCID: PMC10721522.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.

by GSHWORLD

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