Citicoline has "significant clinical effects" in a variety of neurodegenerative diseases such as Alzheimer's disease and stroke, and its mechanism of action may include preservation of cardiolipin and sphingomyelin, restoration of phosphatidylcholine Alkali, stimulate glutathione synthesis, reduce glutamate concentration, rescue mitochondrial function, etc. Previously, some scholars have studied the application of citicoline in glaucoma and obtained good results.
In this randomized, double-blind, placebo-controlled trial, the researchers included 80 open-angle patients who had previously controlled intraocular pressure below 18 mmHg through medication or surgery for at least 2 years, but still had progressive mild to moderate glaucomatous visual field damage. glaucoma patients. In a follow-up 3-year trial, patients were randomized to receive citicoline/placebo eye drops in addition to previous IOP-lowering therapy. During the 3-year follow-up period, there was no significant difference in intraocular pressure between the two groups, and both were controlled below 18mmHg. The study found:
● The progression of visual field damage in the experimental group treated with citicoline eye drops was significantly less than that in the control group: it was close to statistical significance measured by 24-2 Humphrey perimetry (-1.03 vs. -1.92, P = 0.07) , measured by 10-2 Humphrey perimetry was statistically significant (-0.41 vs. -2.22, P=0.02).
▲10-2 Measurement results of Humphrey perimetry
● OCT examination of retinal nerve fiber layer thickness (Retinal Nerve Fiber Layer, RNFL) found that the RNFL damage in the experimental group was also significantly smaller than that in the control group (1.86μm vs. 2.99μm, P = 0.02).
● During the study, citicoline eye drops were well tolerated, and no local or systemic treatment-related side effects were observed, nor did it significantly alter the safety of IOP-lowering therapy.
◆For some patients with open-angle glaucoma, although the intraocular pressure is ≤18 mmHg, the visual field damage is still progressing;
◆ The use of citicoline eye drops as an additional treatment in addition to lowering intraocular pressure can effectively slow down the progression of optic nerve damage.
◆ Citicoline eye drops are well tolerated, and no local or systemic side effects related to treatment have been seen.
*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.