Research from China's Hangzhou Normal University found that NMN and Citicoline may work together to prevent memory decline.
Research by Zhao and colleagues proves:
(1) NMN and citicoline synergistically improve memory in rats with vascular dementia (VD) - dementia caused by a lack of blood flow to the brain.
(2) The combined use of NMN and citicoline can reduce the activation of microglia (the brain’s resident immune cells) that promote inflammation.
(3) The combined use of NMN and citicoline can reduce damage to the white matter tracts of the brain.
As reported in Cellular and Molecular Neurobiology, Zhao and colleagues showed that NMN and citicoline work synergistically to attenuate memory loss in VD rats. They also showed that NMN and citicoline reduced inflammation and brain damage, revealing how the combination of these anti-aging compounds provided greater cognitive protection than taking them alone. The author concluded:
"We have demonstrated that the combination of citicoline and NMN in [VD] rats will maintain the normal body state of neurons, inhibit neuroinflammation in the brain, and ultimately alleviate white matter damage and cognition in [VD] rats disfunction."
References: Zhao, N., Zhu, X., Xie, L. et al. The Combination of Citicoline and Nicotinamide Mononucleotide Induces Neurite Outgrowth and Mitigates Vascular Cognitive Impairment via SIRT1/CREB Pathway. Cell Mol Neurobiol (2023).
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