Radiation encephalopathy (REP) is one of the more serious complications after radiotherapy in patients with nasopharyngeal carcinoma and intracranial tumors. With the prolongation of patients' survival time, the incidence of REP gradually increases, seriously affecting the quality of life of patients.
The incidence rate of REP is 3% to 16%, mainly manifested as acute injury, manifested as headache, nausea, vomiting, epilepsy, disturbance of consciousness, etc., and usually recovers spontaneously after symptomatic, hormone, and dehydration treatment; delayed late injury, The main manifestations are mental retardation, neurological dysfunction, etc. Once it occurs, it is mostly irreversible and progressive. Many patients died not directly from tumors, but from REP.
The most effective treatment for REP is the application of hyperbaric oxygen therapy. At the same time, studies have also proved that hyperbaric oxygen combined with drug therapy for REP can also significantly improve the curative effect and improve the quality of life.
Citicoline is a single nucleotide composed of nucleoside sugar, cytosine, pyrophosphate and choline. As an endogenous compound, citicoline is an important medium for the synthesis of cell membrane phospholipids and is also an important The external source of neurotransmitter-acetylcholine, acetylcholine plays a very important role in nucleotide metabolism, and exogenous administration of citicoline can quickly repair damaged neuron cell membranes by increasing the synthesis of phospholipids, through synaptic The production of acetylcholine in the touch repairs damaged cholinergic neurons, stabilizes the neurotransmitter system, and promotes the energy metabolism of the brain. Exciting nerve cells and protecting cranial nerves.
Babb et al. found that citicoline can promote the synthesis of phosphorylcholine, and phosphorylcholine can improve cognitive function, and the improvement of cognitive function is conducive to better recovery of patients. The disadvantage of citicoline is that it increases oxygen consumption, so it has a synergistic effect with hyperbaric oxygenation, which can enhance the treatment of REP.
Studies have proved that Citicoline Sodium combined with hyperbaric oxygen in the treatment of radiation encephalopathy can effectively increase the curative effect of hyperbaric oxygen in the treatment of radiation encephalopathy. It is an effective treatment for radiation encephalopathy and is worthy of popularization and application. However, whether citicoline sodium combined with hyperbaric oxygen therapy is the most effective treatment for radiation encephalopathy remains to be confirmed by further large-scale experimental studies.