Currently, more and more consumers are paying attention to brain health, including the elderly and young consumers. The former mainly focuses on problems related to cognitive decline, while the latter mainly worries about the psychological impact caused by high pressure and anxiety. Therefore, in the brain health supplement market, products that can not only address the cognitive dysfunction that occurs during the aging process, but also promote mental health and relieve stress, anxiety and emotions are increasingly in demand.
Cognitive functional health is an important component of healthy aging and older adults have emerged as key consumers of the brain health preventative supplement category, mainly due to their fear of developing age-related cognitive diseases such as dementia disease etc.
So what types of ingredients are found in natural products to promote brain health? Many ingredients have been well-studied for improving cognitive health and other psychological issues, and citicoline is one of them.
Citicoline is a pharmaceutical product that is a combination of two natural molecules, cytidine and choline. These endogenous compounds are involved in the biosynthesis of phosphatidylcholine, an important phospholipid of cell membranes. Phosphatidylcholine has long been found in cognitive supplements, and according to one published study, people who consumed a diet rich in this compound developed Alzheimer's disease an average of three years later.
As a commonly used neuroprotective agent, citicoline inhibits the arousal response of the cerebral cortex and the increase of the threshold value of the muscle evoked potential, promotes the ascending reticular activation system, and plays an important role in the recovery of disturbance of consciousness. Citicoline may support multiple aspects of cognitive health by promoting neuroplasticity, resulting in a more agile and robust nervous system.
Citicoline acts on other monoamines, serotonin and norepinephrine, muscarinic and nicotinic receptors, as well as glutamate, opioids and GABA, and plays an important role in the regulation of various intracellular signaling processes effect.
▲Citicoline neuroprotective pathway.
Studies have demonstrated that poorer cardiovascular risk profile is associated with poorer cognitive function and smaller brain volume, areas identified as early predictors of cognitive decline. Exogenous supplementation of citicoline can improve cognitive function. In addition, supplementation of citicoline is also beneficial for cognitive impairment caused by various reasons, stroke sequelae, cerebral hemorrhage, traumatic brain injury and neurodegenerative diseases.