Bone health is crucial to human health, not only determining our physical condition but also determining the quality of life.
Healthy bones and joints are vital to our mobility. Research shows that mortality after a fracture may be significantly increased in older adults.
Joints are composed of articular surfaces, joint capsules, and joint cavities. A fracture refers to a trauma in which a bone is broken, broken or cracked under the action of external force. When a fracture occurs, special stem cells in the bone marrow work through multiple stages to repair and heal the fracture.
These special stem cells, called bone marrow mesenchymal stem cells (BMSCs), are self-regenerative cells capable of differentiating into multiple types of cells, such as osteoblasts and adipocytes, which are key to bone regeneration. Delayed fracture healing or even healing failure is often caused by low activity or dysfunction of BMSCs.
Studies have found that NAD+-mediated mitochondrial OXPHOS is indispensable for the osteogenesis of bone marrow mesenchymal stem cells (BMSCs) and bone repair, and supplementing NMN to increase NAD+ levels may prevent bone marrow mesenchymal stem cells from differentiating into adipose tissue and promote osteogenesis. The formation of bone cells, thereby repairing and regenerating bones and preventing bone aging.
Research shows that as an important metabolite, maintaining intracellular NAD+ levels is necessary for BMSCs to choose the direction of osteogenesis and to maintain mitochondrial function and OXPHOS activity during the osteogenesis process of BMSCs. Therefore, NAD+ is a key factor in bone metabolism. .
Experiments by inhibiting the synthesis of NAD+ in mice found that reducing their NAD+ levels would inhibit their osteogenesis and fracture repair, while supplementing NMN could restore the adverse effects on BMSCs osteogenesis caused by inhibiting NAD+ synthesis and stimulate osteogenesis.
This study found that NMN plays an important role in the differentiation process of bone marrow mesenchymal stem cells, which also means that NMN has important potential in bone repair and bone rejuvenation. We look forward to more experimental and clinical data to promote it.