As an important coenzyme precursor, NMN has shown extraordinary potential in the fields of cellular energy metabolism and anti-aging.
The latest research finds that NMN may make an important contribution to preventing heart failure. Myocardial mitochondria, as a key site of myocardial energy metabolism, are closely linked to heart diseases. Based on NMN research, scientists confirmed through knockout experiments of the mitochondrial translation factor p32 that mitochondrial translation defects not only lead to cardiomyocyte dysfunction but also cause heart failure.
Interestingly, NMN application can partially compensate for the adverse effects of mitochondrial translation defects and reduced NAD+ (nicotinamide adenine dinucleotide) levels. Further research found that NMN can reduce lysosomal damage and improve autophagy function, thereby delaying the occurrence of heart failure.
Myocardial mitochondria are the main site of myocardial energy metabolism, and mitochondrial diseases are related to heart disease.
Studies have found that mice with cardiomyocyte-specific knockout of the mitochondrial translation factor p32 develop heart failure when developing dilated cardiomyopathy. Defects in mitochondrial translation lead to mitochondrial dysfunction and decreased NAD+ levels, which in turn lead to lysosomal acidification and impaired autophagy.
Studies have proven that NMN supplementation can improve mitochondrial dysfunction, reduce lysosomal damage, and improve autophagy, thereby effectively preventing heart failure and extending lifespan.
This suggests that the ameliorative effect of NMN mainly affects lysosomal function rather than mitochondrial function, especially related to lysosome-mediated ferroptosis.
Therefore, NMN supplementation can improve lysosomal function and prevent chronic heart failure.
*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.