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Nicotinamide riboside (NR) has emerged as a popular topic in the health field as a novel nutritional supplement. In addition to its roles in delaying aging, improving cardiovascular health, and combating neurodegenerative diseases, the potential of NR in weight management has also attracted widespread attention.
Research indicates that nicotinamide riboside (NR) supplements can reduce fat accumulation by regulating energy metabolism and fat storage mechanisms. In obese animal models, NR supplementation significantly decreased the weight of fat tissues and the size of fat cells, reducing fat accumulation. This effect may be related to NR’s ability to boost the levels of nicotinamide adenine dinucleotide (NAD+), a key coenzyme in cellular energy metabolism that promotes fat oxidation and energy expenditure.
NR supplements can also increase energy expenditure by activating brown adipose tissue (BAT). BAT is a type of tissue that burns fat to generate heat and plays an important role in energy metabolism. Studies have found that NR supplementation can enhance the activity of BAT, promoting fat burning and thereby helping to reduce body weight.
Obesity and metabolic syndrome are often accompanied by insulin resistance, which further exacerbates fat accumulation and weight gain. NR supplements can improve insulin sensitivity, lower blood glucose levels, and reduce fat synthesis. By enhancing insulin sensitivity, NR helps to better regulate blood sugar and fat metabolism, thereby supporting healthy weight management.
During weight loss, it is important not only to reduce fat but also to maintain muscle mass. Muscle tissue not only helps to maintain the body’s metabolic rate but also keeps the body healthy and functional. Studies have shown that NR supplements can maintain or even increase muscle mass while reducing fat. This may be because NR enhances cellular energy metabolism and protein synthesis, thereby helping to maintain muscle health.
Multiple studies have shown that NR supplements can significantly extend the lifespan of experimental animals and improve their health conditions. In humans, NR supplementation has also been proven to boost the NAD+ metabolome in muscle tissue, induce anti-inflammatory gene expression, and reduce the levels of inflammatory factors, thereby slowing the aging process to some extent.
A clinical trial targeting middle-aged and older adults is investigating the impact of NR supplementation on elevated systolic blood pressure and arterial stiffness. Preliminary research has found that NR supplementation may reduce the risk of cardiovascular diseases by lowering systolic blood pressure and improving arterial stiffness.
In animal models of neurodegenerative diseases such as Alzheimer’s disease (AD) and amyotrophic lateral sclerosis (ALS), NR supplementation has shown significant protective effects. It can reduce neuroinflammation, lower the levels of neuropathological markers, and improve cognitive function.
For the severe liver disease of liver fibrosis, NR supplementation also shows positive effects. It can regulate the TGF-β signaling pathway, inhibit the activation of hepatic stellate cells, reduce collagen deposition, and thereby mitigate the degree of liver fibrosis.
In summary, nicotinamide riboside, as an emerging nutritional supplement, is gradually becoming a new favorite in the health field due to its potential in boosting NAD+ levels, delaying aging, improving symptoms of various diseases, and aiding weight management. However, when choosing NR supplements, we still need to be cautious and preferably do so under the guidance of a professional doctor or nutritionist to ensure their safe and effective health benefits.
[1] EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, Bohn T, et al. Extension of use of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283[J]. EFSA Journal, 2021, 19(11): e06843.
[2] De Castro J M, Stein D J, Medeiros H R, et al. Nicotinamide riboside neutralizes hypothalamic inflammation and increases weight loss without altering muscle mass in obese rats under calorie restriction: a preliminary investigation[J]. Frontiers in Nutrition, 2021, 8: 648893.
[3] Sharma C, Donu D, Cen Y. Emerging role of nicotinamide riboside in health and diseases[J]. Nutrients, 2022, 14(19): 3889.
[4] Freeberg K A, Craighead D H, Martens C R, et al. Nicotinamide riboside supplementation for treating elevated systolic blood pressure and arterial stiffness in midlife and older adults[J]. Frontiers in Cardiovascular Medicine, 2022, 9: 881703.
*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.
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