Nicotinamide Riboside: A New Boost for Health

Nicotinamide riboside (NR), a novel member of the vitamin B3 family, serves as a potent NAD+ precursor with excellent water solubility, strong cellular permeability, and no apparent toxicity. Naturally present in foods such as milk, NR can also be produced through chemical synthesis or chemo-enzymatic methods, commonly available as chloride salts, making it an ideal raw material for dietary supplements.

Metabolic Mechanisms

NR follows a clear and efficient metabolic pathway in the body. Upon entering the human system, it can be absorbed directly or hydrolyzed in the intestine, rapidly converting to nicotinamide in the bloodstream, which then acts as a precursor for NAD+ synthesis. Under the action of NR kinase, NR can also be directly phosphorylated to form nicotinamide mononucleotide, ultimately participating in NAD+ synthesis. Intestinal microbiota can further metabolize NR into various NAD+ precursors, enhancing its bioavailability. Metabolites are primarily excreted through urine in a gentle process that imposes no metabolic burden.

Health Benefits

By elevating intracellular NAD+ levels, NR delivers multifaceted health benefits. It activates sirtuins, improves mitochondrial function, and delays cellular senescence, positively contributing to the maintenance of intestinal stem cell vitality and the improvement of hematopoietic stem cell status. In terms of anti-inflammatory effects, NR can suppress inflammasome activation, reduce pro-inflammatory cytokine levels, and alleviate neuroinflammation and tissue fibrosis. Additionally, it helps regulate metabolic balance and offers potential benefits for cardiovascular health and cognitive function protection, serving as an important nutrient for maintaining overall physiological homeostasis.

Application Prospects

As a nutrient combining safety and functionality, NR’s application scenarios continue to expand. It is already widely used in the dietary supplement sector, while clinical research targeting neurodegenerative diseases, metabolic disorders, and aging-related symptoms is actively progressing. As research deepens, its role in health maintenance and disease intervention will be further elucidated, providing new pathways to support human health.

Reference: Sharma C, Donu D, Cen Y. Emerging Role of Nicotinamide Riboside in Health and Diseases [J]. Nutrients, 2022, 14 (19): 3889.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.

by GSHWORLD

GSH Bio Tech is China Biological API Manufacturer. China Supplements powder suppliers & best benefits raw material Factory.