What is the relationship between glutathione supplementation and the human body?

 

GSH is a tripeptide composed of glutamic acid, cysteine, and glycine. It is synthesized in the cytoplasm through ATP-dependent steps, and the liver is the main source of circulating GSH in the body, so GSH is widely used to protect and restore liver function.

1. The Importance of Glutathione

It is well known that GSSG and GSH levels are indicators of cellular health. Low glutathione levels are an important factor in many diseases. Various diseases will reduce the absorption of cysteine by cells and lead to the loss of glutathione. Reduced GSH levels are common in liver diseases, such as non-alcoholic fatty liver disease, alcohol Sexual liver disease, ischemia/reperfusion injury, hepatitis C, hepatitis B and liver cancer, etc.

2. The relationship between glutathione levels and the body:

①Exercise fatigue is a normal physiological phenomenon caused by muscle activity. Animal experiments have found that exogenous supplementation of GSH can reduce non-esterified fatty acids in plasma, increase intramuscular pH, inhibit the increase in intramuscular lactic acid, improve metabolism and alleviate long-term activity. Produced muscle fatigue.

②The brain is particularly sensitive to oxidative stress damage. As we age, oxidative stress becomes a cause of neurodegenerative diseases. A large number of studies have shown that GSH acts as a neuromodulator in the nervous system and can inhibit oxidative stress. mediated destruction.

③A common disease of the digestive system is liver disease. Exogenous GSH can reduce liver function damage indicators, increase SOD and glutathione peroxidase activities, and protect the liver.

Supplementing synthetic glutathione or precursors can increase intracellular glutathione levels and protect cells from damage.

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*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.