NMN may reduce aging-related dysfunction
The world-renowned medical journal "The Lancet" once published a major study showing that the liver damage caused by long-term drinking is initially manifested as fatty liver, which can develop into alcoholic hepatitis, liver fibrosis, cirrhosis and liver cancer. lead to liver failure.
In May 2022, Deng Haiteng's research group from Tsinghua University published a paper in the top journal "Cells" again.
They found that 4 weeks of NMN supplementation can improve the overall increase in protein acetylation caused by liver aging.
Reduces age-related dysfunction and also regulates fatty acid beta oxidation, tricarboxylic acid cycle, and valine degradation.
The researchers selected young mice (8 weeks old) and old mice (96 weeks old) for experiments, and injected NMN (500 mg/kg) or phosphate buffered saline (PBS, control ), continued for 4 weeks, and analyzed the biochemical indicators of mice in each group.
Figure : Comparison of MDA and PCO levels in the liver of aged and young mice
Through proteome analysis of aged mice and young mice, it was found that compared with young livers, 273 proteins were increased and 537 proteins were decreased in the livers of aged mice.
Most of these proteins are related to redox process, indicating that aging is destructive to redox homeostasis.
by GSHWORLD
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